Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase.

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Shushmita Chand, Alok Shiomurti Tripathi, Tabinda Hasan, Kavitha Ganesh, Mary Anne W Cordero, Mohammad Yasir, Magdi E A Zaki, Pankaj Tripathi, Lucy Mohapatra, Rahul Kumar Maurya
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Abstract

Objectives: Present report evaluates the protective effect of geraniol on high fat diet (HFD) induced obesity in rats and also determines the molecular mechanism of it.

Methods: Rats were induced with obesity with administration of HFD for four weeks and geraniol 200 and 400 mg/kg p.o. was administered for the next four week in the respective groups. Blood glucose and oral glucose tolerance test (OGTT), lipid profile was estimated in the geraniol treated HFD induced obesity in rats. Moreover, docking study was performed to determine the specific mechanism of geraniol by targeting HMG-CoE A reductase (in silico).

Results: There was significant increase in body weight and amelioration in altered serum glucose and lipid profile were observed in the geraniol treated group than negative control group. Weight of organs and adipose tissue isolated from different regions of the body was reduced in geraniol treated group than negative control. Moreover, geraniol interact with HMG-CoA reductase having binding energy -5.13.

Conclusions: In conclusion, data of the report reveals that geraniol reduces obesity by promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT), as it interacts with HMG-CoA reductase in HFD induced obesity in rats.

Abstract Image

香叶醇通过抑制 HMGCoA 还原酶,改善高脂饮食诱导的肥胖大鼠体内 WAT 向 BAT 的转化,从而逆转肥胖。
目的:本报告评估了香叶醇对高脂饮食(HFD)诱导大鼠肥胖的保护作用,并确定了其分子机制:本报告评估了香叶醇对高脂饮食(HFD)诱导的大鼠肥胖症的保护作用,并确定了其分子机制:方法:用高脂饮食(HFD)诱导大鼠肥胖四周,然后在接下来的四周内分别给各组大鼠注射 200 和 400 mg/kg p.o.的香叶醇。对使用香叶醇处理高氟日粮诱发肥胖的大鼠进行血糖和口服葡萄糖耐量试验(OGTT)以及血脂测定。此外,还进行了对接研究,以确定香叶醇靶向 HMG-CoE A 还原酶的具体机制(硅学):结果:与阴性对照组相比,香叶醇处理组大鼠的体重明显增加,血清葡萄糖和血脂的变化也有所改善。与阴性对照组相比,香叶醇处理组从身体不同部位分离出的器官和脂肪组织的重量均有所减少。此外,香叶醇与 HMG-CoA 还原酶的结合能为-5.13:总之,报告数据显示,在高密度脂蛋白胆固醇(HFD)诱导的大鼠肥胖症中,香叶醇通过与 HMG-CoA 还原酶相互作用,促进白色脂肪组织(WAT)向棕色脂肪组织(BAT)转化,从而减少肥胖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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