Aqueous extract of Laurus nobilis leaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Research and Practice Pub Date : 2023-12-01 Epub Date: 2023-09-20 DOI:10.4162/nrp.2023.17.6.1113
Jae In Jung, Yean-Jung Choi, Jinhak Kim, Kwang-Soo Baek, Eun Ji Kim
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引用次数: 0

Abstract

Background/objectives: Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats.

Materials/methods: LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured.

Results: LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx.

Conclusions: LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.

月桂叶水提取物可加速酒精代谢,防止单次酒精狂饮大鼠的肝损伤。
背景/目的:过量饮酒对健康有害,包括宿醉和与酒精相关的肝病。因此,需要加快酒精代谢的方法。月桂是一种香料、调味剂和治疗各种疾病的传统草药。本研究探讨了标准化的月桂叶水提取物(LN)是否能加速单次酒精狂欢的斯普拉格-道利(SD)大鼠的酒精代谢并保护其免受肝损伤:在给 SD 大鼠注射乙醇(3 克/千克体重[BW])前 1 小时口服 LN,剂量为 100 毫克/千克体重和 300 毫克/千克体重。乙醇给药后 0.5、1、2 和 4 小时采集血液样本。服用乙醇 1 小时后切除肝脏,测定肝酶活性。测定肝组织中乙醇脱氢酶(ADH)、醛脱氢酶(ALDH)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)的活性:结果:LN 降低了乙醇给药大鼠的血清乙醇和乙醛水平。LN 提高了乙醇给药大鼠肝脏 ADH 和 ALDH 的活性,但降低了丙氨酸氨基转移酶、天冬氨酸氨基转移酶和γ-谷氨酰转移酶的活性。此外,LN 还能抑制脂质过氧化,提高 SOD 和 GPx 的活性:结论:LN 可调节过量饮酒的各种病因效应介质,增强酒精代谢和抗氧化活性,是治疗宿醉的潜在候选药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
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