Association between Smoking Status and the Risk of Hip Fracture in Patients with Type 2 Diabetes: A Nationwide Population-Based Study.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrinology and Metabolism Pub Date : 2023-12-01 Epub Date: 2023-12-06 DOI:10.3803/EnM.2023.1760

Se-Won Lee, Jun-Young Heu, Ju-Yeong Kim, Jinyoung Kim, Kyungdo Han, Hyuk-Sang Kwon

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引用次数: 0

Abstract

Backgruound: Limited longitudinal evidence exists regarding the potential association between smoking status and hip fracture among individuals with type 2 diabetes. We investigated this association using large-scale, nationwide cohort data for the Korean population.

Methods: This nationwide cohort study included 1,414,635 adults aged 40 and older who received Korean National Health Insurance Service health examinations between 2009 and 2012. Subjects with type 2 diabetes were categorized according to their smoking status, amount smoked (pack-years), number of cigarettes smoked per day, and duration of smoking. The results are presented as hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between smoking status parameters and risk of hip fracture in multivariable Cox proportional hazard regression analysis.

Results: Compared with never-smokers, an increased adjusted HR (aHR) for hip fracture was observed in current smokers (1.681; 95% CI, 1.578 to 1.791), and a comparable aHR for hip fracture was found in former smokers (1.065; 95% CI, 0.999 to 1.136). For former smokers who had smoked 20 pack-years or more, the risk was slightly higher than that for never-smokers (aHR, 1.107; 95% CI, 1.024 to 1.196). The hip fracture risk of female former smokers was similar to that of female current smokers, but the hip fracture risk in male former smokers was similar to that of male never-smokers.

Conclusion: Smoking is associated with an increased risk of hip fracture in patients with type 2 diabetes. Current smokers with diabetes should be encouraged to quit smoking because the risk of hip fracture is greatly reduced in former smokers.

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2 型糖尿病患者吸烟状况与髋部骨折风险之间的关系：一项基于全国人口的研究。

背景：有关 2 型糖尿病患者吸烟状况与髋部骨折之间潜在关系的纵向证据有限。我们利用大规模、全国性的韩国人群队列数据研究了这一关联：这项全国性队列研究纳入了 1,414,635 名年龄在 40 岁及以上、在 2009 年至 2012 年期间接受过韩国国民健康保险服务健康检查的成年人。根据受试者的吸烟状况、吸烟量（包年）、每天吸烟支数和吸烟持续时间，对2型糖尿病受试者进行分类。结果以危险比（HRs）和95%置信区间（CIs）的形式显示了多变量考克斯比例危险回归分析中吸烟状态参数与髋部骨折风险之间的关系：与从不吸烟者相比，目前吸烟者发生髋部骨折的调整HR（aHR）增加（1.681；95% CI，1.578 至 1.791），曾经吸烟者发生髋部骨折的调整HR（aHR）与之相当（1.065；95% CI，0.999 至 1.136）。对于吸烟 20 包年或以上的曾经吸烟者，其髋部骨折风险略高于从未吸烟者（aHR，1.107；95% CI，1.024 至 1.196）。女性曾经吸烟者的髋部骨折风险与女性目前吸烟者的髋部骨折风险相似，但男性曾经吸烟者的髋部骨折风险与男性从不吸烟者的髋部骨折风险相似：结论：吸烟与 2 型糖尿病患者髋部骨折风险增加有关。结论：吸烟与 2 型糖尿病患者髋部骨折风险的增加有关，应鼓励目前吸烟的糖尿病患者戒烟，因为曾经吸烟的患者髋部骨折的风险会大大降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.60

自引率

5.90%

发文量

145

审稿时长

24 weeks

期刊介绍： The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).