Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties

IF 6.7 1区 医学 Q1 CHEMISTRY, MEDICINAL
Hai-bo Zhou , Sheng-ze Lu , Zhong-shun Yu , Jiu-liang Zhang , Zhi-nan Mei
{"title":"Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties","authors":"Hai-bo Zhou ,&nbsp;Sheng-ze Lu ,&nbsp;Zhong-shun Yu ,&nbsp;Jiu-liang Zhang ,&nbsp;Zhi-nan Mei","doi":"10.1016/j.phymed.2023.155251","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Insomnia and depressive disorder are two common symptoms with a reciprocal causal relationship in clinical practice, which are usually manifested in comorbid form. Several medications have been widely used in the treatment of insomnia and depression, but most of these drugs show non-negligible side effects. Currently, many treatments are indicated for insomnia and depressive symptom, including Chinese herbal medicine such as <em>Gastrodia elata</em> Blume (<em>G. elata</em>), which has excellent sedative-hypnotic and antidepressant effects in clinical and animal studies.</p></div><div><h3>Purpose</h3><p>To summarize the mechanisms of insomnia and depression and the structure-activity mechanism for <em>G. elata</em> to alleviate these symptoms, particularly by hypothalamic-pituitary-adrenal (HPA) axis and intestinal flora, aiming to discover new approaches for the treatment of insomnia and depression.</p></div><div><h3>Methods</h3><p>The following electronic databases were searched from the beginning to November 2023: PubMed, Web of Science, Google Scholar, Wanfang Database, and CNKI. The following keywords of <em>G. elata</em> were used truncated with other relevant topic terms, such as depression, insomnia, antidepressant, sedative-hypnotic, neuroprotection, application, safety, and toxicity.</p></div><div><h3>Results</h3><p>Natural compounds derived from <em>G. elata</em> could alleviate insomnia and depressive disorder, which is involved in monoamine neurotransmitters, inflammatory response, oxidative stress, and gut microbes, etc. Several clinical trials showed that <em>G. elata</em>-derived natural compounds that treat depression and insomnia have significant and safe therapeutic effects, but further well-designed clinical and toxicological studies are needed.</p></div><div><h3>Conclusion</h3><p><em>G. elata</em> exerts a critical role in treating depression and insomnia due to its multi-targeting properties and fewer side effects. However, more clinical and toxicological studies should be performed to further explore the sedative-hypnotic and antidepressant mechanisms of <em>G. elata</em> and provide more evidence and recommendations for its clinical application. Our review provides an overview of <em>G. elata</em> treating insomnia with depression for future research direction.</p></div>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"123 ","pages":"Article 155251"},"PeriodicalIF":6.7000,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytomedicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0944711323006104","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Insomnia and depressive disorder are two common symptoms with a reciprocal causal relationship in clinical practice, which are usually manifested in comorbid form. Several medications have been widely used in the treatment of insomnia and depression, but most of these drugs show non-negligible side effects. Currently, many treatments are indicated for insomnia and depressive symptom, including Chinese herbal medicine such as Gastrodia elata Blume (G. elata), which has excellent sedative-hypnotic and antidepressant effects in clinical and animal studies.

Purpose

To summarize the mechanisms of insomnia and depression and the structure-activity mechanism for G. elata to alleviate these symptoms, particularly by hypothalamic-pituitary-adrenal (HPA) axis and intestinal flora, aiming to discover new approaches for the treatment of insomnia and depression.

Methods

The following electronic databases were searched from the beginning to November 2023: PubMed, Web of Science, Google Scholar, Wanfang Database, and CNKI. The following keywords of G. elata were used truncated with other relevant topic terms, such as depression, insomnia, antidepressant, sedative-hypnotic, neuroprotection, application, safety, and toxicity.

Results

Natural compounds derived from G. elata could alleviate insomnia and depressive disorder, which is involved in monoamine neurotransmitters, inflammatory response, oxidative stress, and gut microbes, etc. Several clinical trials showed that G. elata-derived natural compounds that treat depression and insomnia have significant and safe therapeutic effects, but further well-designed clinical and toxicological studies are needed.

Conclusion

G. elata exerts a critical role in treating depression and insomnia due to its multi-targeting properties and fewer side effects. However, more clinical and toxicological studies should be performed to further explore the sedative-hypnotic and antidepressant mechanisms of G. elata and provide more evidence and recommendations for its clinical application. Our review provides an overview of G. elata treating insomnia with depression for future research direction.

Abstract Image

天麻及其成分的生物活性机制:镇静催眠和抗抑郁特性的综合综述
背景:在临床实践中,睡眠障碍与抑郁症是两种常见的互为因果关系的症状,通常以合并症的形式表现。有几种药物被广泛用于治疗失眠和抑郁症,但这些药物中的大多数都有不可忽视的副作用。目前,许多治疗失眠和抑郁症状的方法,包括中草药天麻(G. elata Blume),在临床和动物研究中具有优异的镇静催眠和抗抑郁作用。目的总结桂花失眠、抑郁的机制及桂花缓解失眠、抑郁的构效机制,特别是通过下丘脑-垂体-肾上腺(HPA)轴和肠道菌群的作用,探索治疗失眠、抑郁的新途径。方法检索年初至2023年11月的电子数据库:PubMed、Web of Science、Google Scholar、万方数据库、中国知网。以下关键词与其他相关主题术语进行截断,如抑郁、失眠、抗抑郁、镇静催眠、神经保护、应用、安全性和毒性。结果栀子提取物具有减轻失眠和抑郁障碍的作用,其机制涉及单胺类神经递质、炎症反应、氧化应激和肠道微生物等。多项临床试验表明,苦参衍生的天然化合物治疗抑郁症和失眠具有显著和安全的疗效,但还需要进一步精心设计的临床和毒理学研究。Elata由于其多靶点特性和较少的副作用,在治疗抑郁症和失眠方面发挥了关键作用。但是,还需要开展更多的临床和毒理学研究,进一步探索其镇静催眠和抗抑郁的作用机制,为其临床应用提供更多的证据和建议。本文综述了桂花治疗失眠伴抑郁的研究进展,为今后的研究方向提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Phytomedicine
Phytomedicine 医学-药学
CiteScore
10.30
自引率
5.10%
发文量
670
审稿时长
91 days
期刊介绍: Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信