Puberty Assessment and Consideration of Gonadotropin-Releasing Hormone Agonists in Transgender and Gender-Diverse Youth.

IF 1.1 4区 医学 Q3 PEDIATRICS
Janet Y Lee
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引用次数: 0

Abstract

Transgender and gender-diverse (TGD) youth may pursue gender-affirming medical therapy in the form of gonadotropin-releasing hormone analogues (GnRHa), or "puberty blockers," if pubertal changes result in the development or worsening of gender dysphoria. GnRHa monotherapy can allow TGD youth to explore gender without the distress of unwanted secondary sexual characteristics. However, given the potential effects of GnRHa on growth, skeletal development, neurodevelopment, fertility, and future surgical outcomes, it is critical to accurately assess pubertal status to facilitate fully informed conversations with TGD youth and families about risks, benefits, and unknown consequences of GnRHa monotherapy. The focus of this discussion will be on the approach to puberty assessment in TGD youth as well as the different effects of GnRHa monotherapy that may be important to TGD youth and their families. [Pediatr Ann. 2023;52(12):e462-e466.].

青春期评估和考虑促性腺激素释放激素激动剂在跨性别和性别多样化的青年。
如果青春期的变化导致性别焦虑的发展或恶化,跨性别和性别多样化(TGD)的青少年可能会寻求以促性腺激素释放激素类似物(GnRHa)或“青春期阻断剂”的形式进行性别确认医学治疗。GnRHa单药疗法可以让TGD青年探索性别,而不会因为不想要的第二性征而苦恼。然而,考虑到GnRHa对生长、骨骼发育、神经发育、生育和未来手术结果的潜在影响,准确评估青春期状态以促进与TGD青年和家庭充分了解GnRHa单药治疗的风险、益处和未知后果至关重要。本次讨论的重点是TGD青少年的青春期评估方法,以及GnRHa单药治疗的不同效果,这可能对TGD青少年及其家人很重要。[j].中华儿科杂志,2013;32(6):562 - 566。
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来源期刊
Pediatric Annals
Pediatric Annals 医学-小儿科
CiteScore
1.80
自引率
0.00%
发文量
104
审稿时长
2 months
期刊介绍: Published for more than 40 years, Pediatric Annals is an online-only, monthly medical review journal dedicated to providing pediatricians and other clinicians with the latest practical information on the diagnosis and treatment of pediatric diseases and disorders. Begin to explore the Journal and all of its great benefits such as: -Single-topic summary reviews of important trends in pediatric medicine -Access to current articles, as well as several years of archived content -Columns including Healthy Baby/Healthy Child and Case Challenges
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