Skin and soft tissue infections in solid organ transplants.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-04-01 Epub Date: 2023-12-04 DOI:10.1097/QCO.0000000000000998

Maddalena Peghin, Elena Graziano, Paolo Antonio Grossi

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Abstract

Purpose of review: Skin and soft tissue infections (SSTI) in solid organ transplant (SOT) recipients may be a great challenge for clinicians caring for SOT due to the involvement of both common and opportunistic pathogens associated with a blunted immune response. The purpose of this review is to outline current literature and describe open issues on the management of SSTI in this special population.

Recent findings: Clinical presentation in SOT recipients can manifest as isolated skin lesions after primary inoculation or be the sign of a disseminated infection. Tissue samples for microscopy and histopathology are crucial to making an accurate diagnosis given the nonspecific and heterogeneous appearance of skin lesions. Multidisciplinary teams are required for a comprehensive diagnosis and management.

Summary: SSTI are frequent contributors to morbidity and mortality in SOT. Specific research focused on the clinical presentation, risk factors and management in this special population is needed.

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实体器官移植中的皮肤和软组织感染。

综述目的:实体器官移植(SOT)受者的皮肤和软组织感染(SSTI)可能是临床医生照顾SOT的一个巨大挑战，因为与迟钝的免疫反应相关的常见和机会性病原体的参与。本综述的目的是概述当前文献，并描述这一特殊人群中SSTI管理的开放性问题。最近发现:SOT受者的临床表现可表现为初次接种后孤立的皮肤病变或播散性感染的迹象。组织样本的显微镜和组织病理学是至关重要的作出准确的诊断给予非特异性和异质外观的皮肤病变。需要多学科团队进行综合诊断和管理。总结:SSTI是SOT发病率和死亡率的常见原因。需要对这一特殊人群的临床表现、危险因素和管理进行专门的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.