Socioeconomic status as determinant for the development of comorbidities in adults with type 1 diabetes: A nationwide register study in Denmark from 1996–2018

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-30 DOI:10.1016/j.deman.2023.100190

Jonas D. Andersen , Carsten W. Stoltenberg , Morten H. Jensen , Peter Vestergaard , Ole Hejlesen , Stine Hangaard

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引用次数: 0

Abstract

Aims

To describe the incidence of type 1 diabetes (T1D), and incidence of comorbidities in addition to T1D, in adults over a 22-year period in Denmark and explore the associations between socioeconomic status (SES) and the development of comorbidities.

Methods

We conducted a retrospective cohort study on nationwide registry data to describe incidences of T1D and comorbidities in adults (≥21 years) from 1996 to 2018. People were followed from T1D diagnosis until a first event of interest, death, or end of follow-up, whichever came first. Cox proportional hazards models were used to quantify the associations between SES and development of comorbidities.

Results

We included 7877 adults with T1D. Overall, the incidence of T1D decreased (411 in 1996 to 191 in 2018) while it increased for comorbidities in addition to T1D (< 3 to 38 and 10 to 53). Low education and income, compared to higher counterparts, increased the risks of comorbidity by 55 % (HR 1.55, 95 % CI 1.36–1.77) and 82 % (HR 1.82, 95 % CI 1.60–2.06), respectively.

Conclusions

Low SES increases the risk of comorbidities in adults with T1D. This indicates that SES is an important factor to consider when aiming to prevent or predict development of comorbidities in adults with T1D.

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社会经济地位是成人1型糖尿病合并症发展的决定因素:1996-2018年丹麦全国登记研究

目的描述22年来丹麦成人1型糖尿病(T1D)的发病率以及除T1D外的合并症的发病率，并探讨社会经济地位(SES)与合并症发展之间的关系。方法对1996年至2018年全国登记数据进行回顾性队列研究，以描述成人(≥21岁)T1D的发病率和合并症。患者从T1D诊断开始随访，直到第一次感兴趣的事件、死亡或随访结束，以先发生者为准。Cox比例风险模型用于量化SES与合并症发生之间的关系。结果纳入成年T1D患者7877例。总体而言，T1D的发病率下降(1996年为411例，2018年为191例)，而除T1D外的合并症发病率上升(<3到38和10到53)。低教育程度和收入的人群，与高教育水平的人群相比，共病风险分别增加了55% (HR 1.55, 95% CI 1.36-1.77)和82% (HR 1.82, 95% CI 1.60-2.06)。结论慢速SES增加了成人T1D患者合并症的风险。这表明SES是预防或预测成人T1D合并症发展时需要考虑的重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.