USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities

IF 2.3 3区 生物学 Q3 BIOCHEMICAL RESEARCH METHODS
Si-Ting Gao , Xin Xin , Zhuo-yuan Wang , Yi-yang Hu , Qin Feng
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引用次数: 0

Abstract

Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5. Additionally, we discuss the role of USP5 in regulating diverse cellular processes, including cell proliferation, apoptosis, DNA double-strand damage, methylation, heat stress, and protein quality control, by targeting different substrates. Furthermore, we describe the involvement of USP5 in several pathological conditions such as tumors, pathological pain, developmental abnormalities, inflammatory diseases, and virus infection. Finally, we introduce newly developed inhibitors of USP5. In conclusion, investigating the novel functions and substrates of USP5, elucidating the underlying mechanisms of USP5-substrate interactions, intensifying the development of inhibitors, and exploring the upstream regulatory mechanisms of USP5 in detail can provide a new theoretical basis for the treatment of various diseases, including cancer, which is a promising research direction with considerable potential. Overall, USP5 plays a critical role in regulating various physiological and pathological processes, and investigating its novel functions and regulatory mechanisms may have significant implications for the development of therapeutic strategies for cancer and other diseases.

Abstract Image

USP5:对结构、功能、生物学和疾病相关意义的全面见解,以及新兴的治疗机会
泛素特异性蛋白酶5 (Ubiquitin specific protease 5, USP5)是一种重要的去泛素化酶,通过去除靶蛋白上的泛素链来调节各种生理功能。本文就USP5的结构和功能特点作一综述。此外,我们讨论了USP5在调节多种细胞过程中的作用,包括细胞增殖、凋亡、DNA双链损伤、甲基化、热应激和蛋白质质量控制,通过靶向不同的底物。此外,我们还描述了USP5参与多种病理条件,如肿瘤、病理性疼痛、发育异常、炎症性疾病和病毒感染。最后,我们介绍了新开发的USP5抑制剂。综上所述,研究USP5的新功能和底物,阐明USP5-底物相互作用的潜在机制,加强抑制剂的开发,详细探索USP5的上游调控机制,可以为包括癌症在内的多种疾病的治疗提供新的理论基础,是一个很有前景的研究方向,具有相当的潜力。综上所述,USP5在调节多种生理和病理过程中发挥着关键作用,研究其新功能和调控机制可能对癌症和其他疾病的治疗策略的制定具有重要意义。
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来源期刊
Molecular and Cellular Probes
Molecular and Cellular Probes 生物-生化研究方法
CiteScore
6.80
自引率
0.00%
发文量
52
审稿时长
16 days
期刊介绍: MCP - Advancing biology through–omics and bioinformatic technologies wants to capture outcomes from the current revolution in molecular technologies and sciences. The journal has broadened its scope and embraces any high quality research papers, reviews and opinions in areas including, but not limited to, molecular biology, cell biology, biochemistry, immunology, physiology, epidemiology, ecology, virology, microbiology, parasitology, genetics, evolutionary biology, genomics (including metagenomics), bioinformatics, proteomics, metabolomics, glycomics, and lipidomics. Submissions with a technology-driven focus on understanding normal biological or disease processes as well as conceptual advances and paradigm shifts are particularly encouraged. The Editors welcome fundamental or applied research areas; pre-submission enquiries about advanced draft manuscripts are welcomed. Top quality research and manuscripts will be fast-tracked.
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