Advancing food safety risk assessment in China: development of new approach methodologies (NAMs).

IF 3.6 Q2 TOXICOLOGY
Frontiers in toxicology Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI:10.3389/ftox.2023.1292373
Daoyuan Yang, Hui Yang, Miaoying Shi, Xudong Jia, Haixia Sui, Zhaoping Liu, Yongning Wu
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Abstract

Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-animal methodologies such as in vitro and in silico approaches. The United States Environmental Protection Agency and the European Food Safety Authority have established work plans to encourage the development and application of NAMs in NGRA. Currently, NAMs are more commonly used in research than in regulatory risk assessment. China is also developing NAMs for NGRA but without a comprehensive review of the current work. This review summarizes major NAM-related research articles from China and highlights the China National Center for Food Safety Risk Assessment (CFSA) as the primary institution leading the implementation of NAMs in NGRA in China. The projects of CFSA on NAMs such as the Food Toxicology Program and the strategies for implementing NAMs in NGRA are outlined. Key issues and recommendations, such as discipline development and team building, are also presented to promote NAMs development in China and worldwide.

推进中国食品安全风险评估:新方法方法(NAMs)的发展。
新的技术和方法正在发展,以推进食品安全风险评估进入下一代。考虑到传统动物试验的缺点,新方法方法学(NAMs)将成为下一代风险评估(NGRA)的主要工具,使用非动物方法,如体外和计算机方法。美国环境保护局和欧洲食品安全局制定了工作计划,以鼓励在国家食品安全评估中开发和应用nama。目前,NAMs更多地用于研究而不是监管风险评估。中国也在为NGRA开发nama,但没有对当前工作进行全面审查。本文综述了中国主要的namas相关研究文章,并强调中国食品安全风险评估中心(CFSA)是中国NGRA中namas实施的主要机构。概述了食品安全总局在食品毒理学计划等方面的研究项目以及在国家食品安全管理局实施NAMs的策略。本文还提出了学科发展和团队建设等关键问题和建议,以促进NAMs在中国和世界范围内的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
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审稿时长
13 weeks
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