Utility of the Systemic Inflammation Response Index as a Predictor of Pneumonia After Spontaneous Intracerebral Hemorrhage.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Neurologist Pub Date : 2024-07-01 DOI:10.1097/NRL.0000000000000538

Tingting Yu, Zhengyang Wang

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引用次数: 0

Abstract

Objective: We sought to determine whether the initial Systemic Inflammatory Response Index (SIRI) was associated with pneumonia after spontaneous intracerebral hemorrhage (SICH) in hospitalized patients.

Patients and methods: Patients with SICH admitted to Taizhou People's Hospital between January 2019 and December 2021 were retrospectively analyzed. Baseline variables were compared between stroke-associated pneumonia (SAP) and non-SAP groups. Multivariable logistic regression analyses were utilized to calculate the relationship between SIRI and SAP risk.

Results: Of 495 patients included in this research, 192 (38.79%) developed SAP ultimately. The SIRI values exhibited the highest area under the curve value for SAP incidence (area under the curve = 0.736, 95% CI: 0.692-0.781), with respective sensitivity and specificity values of 0.646 and 0.749 at the optimal cutoff threshold of 2.53. In multivariate analysis, high SIRI (≥2.53) was a significant independent predictor of post-SICH SAP even after controlling for other possible confounding variables (odds ratio: 5.11, 95% CI: 2.89-9.04, P < 0.001). According to the restricted cubic splines model, SAP risk increases as SIRI increases.

Conclusions: We observed that SIRI values may offer high diagnostic utility as a predictor of SAP risk among patients with SICH during the early stages of the disease.

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系统性炎症反应指数作为自发性脑出血后肺炎预测因子的应用。

目的:我们试图确定住院患者自发性脑出血(siich)后的初始全身炎症反应指数(SIRI)是否与肺炎相关。患者与方法:回顾性分析2019年1月至2021年12月泰州市人民医院收治的siich患者。比较卒中相关性肺炎(SAP)组和非SAP组的基线变量。采用多变量logistic回归分析计算SIRI与SAP风险之间的关系。结果:纳入研究的495例患者中，192例(38.79%)最终发展为SAP。SIRI值显示SAP发病率曲线下面积最高(曲线下面积= 0.736,95% CI: 0.692-0.781)，在最佳截止阈值为2.53时，其敏感性和特异性分别为0.646和0.749。在多变量分析中，即使在控制了其他可能的混杂变量后，高SIRI(≥2.53)仍是sich后SAP的显著独立预测因子(优势比:5.11,95% CI: 2.89-9.04, P < 0.001)。根据受限三次样条模型，SAP风险随SIRI的增加而增加。结论:我们观察到SIRI值可以作为siich患者在疾病早期SAP风险的预测因子提供高诊断效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.