Self-Reported Fatigue by the Chalder Fatigue Questionnaire and Mortality in Brazilian Hemodialysis Patients: The PROHEMO.

IF 2.3 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephron Pub Date : 2024-01-01 Epub Date: 2023-12-02 DOI:10.1159/000533472

Gabriel Brayan Gutiérrez-Peredo, Márcia Tereza Silva Martins, Fernanda Albuquerque da Silva, Marcelo Barreto Lopes, Gildete Barreto Lopes, Keith C Norris, Antonio Alberto Lopes

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Abstract

Background: The existing data support the Chalder Fatigue Questionnaire (CFQ-11) as a valid instrument to assess fatigue in maintenance hemodialysis (MHD) patients. The objective of this work was to investigate whether self-reported fatigue can serve as an independent prognostic indicator for mortality in MHD patients.

Methods: The data are from 233 adult patients enrolled in the cohort "The Prospective Study of the Prognosis of Chronic Hemodialysis Patients" (PROHEMO) developed in Salvador, BA, Brazil. The Brazilian version of the validated CFQ-11 was used to calculate self-reported fatigue. The CFQ-11 scores may range from 0 to 33; higher scores represent more fatigue. Fatigue categories were created based on proposed cut point: absence or mild degree if CFQ-11 scores <4 and moderate to severe if scores ≥4. Cox models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of associations between fatigue and mortality with adjustments for sociodemographic factors, time on dialysis, education, economic class, hemoglobin concentration, diabetes, heart failure, depression, and other psychiatric disorders.

Results: The mean age was 51.5 ± 2.5 years, 58% were male, and 30% were diabetic. Self-reported moderate to severe fatigue was reported by 71% of patients. The mortality rate was 8.6 cases/100 person-years. Patients with moderate to severe fatigue had a more than threefold mortality rate (HR = 3.07, 95% CI: 1.19, 7.93) compared to patients with absent or mild fatigue, after extensive adjustments for covariates.

Conclusion: The study provides evidence that self-reported fatigue can help identify MHD patients at higher risk of earlier death.

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巴西血液透析患者自我报告疲劳的Chalder疲劳问卷和死亡率:PROHEMO。

背景:现有数据支持Chalder疲劳问卷(CFQ-11)作为评估维持性血液透析(MHD)患者疲劳的有效工具。这项工作的目的是调查自我报告的疲劳是否可以作为MHD患者死亡率的独立预后指标。方法:数据来自巴西萨尔瓦多BA开展的“慢性血液透析患者预后前瞻性研究”(PROHEMO)队列中的233名成年患者。经过验证的巴西版CFQ-11被用来计算自我报告的疲劳。CFQ-11的得分范围从0到33;分数越高代表越疲劳。根据CFQ-11评分的建议切点:无疲劳或轻度疲劳划分疲劳类别。结果:平均年龄为51.5±2.5岁，男性占58%，糖尿病患者占30%。71%的患者自我报告中度至重度疲劳。死亡率为8.6例/100人年。在对协变量进行广泛调整后，中度至重度疲劳患者的死亡率是无疲劳或轻度疲劳患者的三倍以上(HR = 3.07, 95% CI: 1.19, 7.93)。结论:该研究提供了证据，证明自我报告的疲劳可以帮助识别早期死亡风险较高的MHD患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron UROLOGY & NEPHROLOGY-

CiteScore

5.00

自引率

0.00%

发文量

期刊介绍： ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.