{"title":"Air pollution after acute bronchiolitis is a risk factor for preschool asthma: a nested case-control study.","authors":"Hao-Wei Chung, Hui-Min Hsieh, Chung-Hsiang Lee, Yi-Ching Lin, Yu-Hsiang Tsao, Ming-Chu Feng, Chih-Hsing Hung","doi":"10.1186/s12940-023-01035-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis.</p><p><strong>Methods: </strong>A nested case-control retrospective study was performed at the Kaohsiung Medical University Hospital systems between 2009 and 2019. The average concentration of PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, NO, NO<sub>2,</sub> and NO<sub>X</sub> was collected for three, six, and twelve months after the first infected episode. Adjusted regression models were employed to evaluate the association between asthma and air pollution exposure after bronchiolitis.</p><p><strong>Results: </strong>Two thousand six hundred thirty-seven children with acute bronchiolitis were included. Exposure to PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub>, NO, NO<sub>2,</sub> and NO<sub>X</sub> in the three, six, and twelve months following an episode of bronchiolitis was found to significantly increase the risk of preschool asthma in infants with a history of bronchiolitis.(OR, 95%CI: PM<sub>10</sub> = 1.517-1.559, 1.354-1.744; PM<sub>2.5</sub> = 2.510-2.603, 2.148-3.061; SO<sub>2</sub> = 1.970-2.040, 1.724-2.342; ; NO = 1.915-1.950, 1.647-2.272; NO<sub>2</sub> = 1.915-1.950, 1.647-2.272; NO<sub>X</sub> = 1.752-1.970, 1.508-2.252) In a sensitive analysis of hospitalized infants, only PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2,</sub> and NO were found to have significant effects during all time periods. (OR, 95%CI: PM<sub>10</sub> = 1.613-1.650, 1.240-2.140; PM<sub>2.5</sub> = 2.208-2.286, 1.568-3.061; SO<sub>2</sub> = 1.679-1.622, 1.197-2.292; NO = 1.525-1.557, 1.094-2.181) CONCLUSION: The presence of ambient PM<sub>10</sub>, PM<sub>2.5</sub>, SO<sub>2</sub> and NO in the three, six, and twelve months following an episode of acute bronchiolitis has been linked to the development of preschool asthma in infants with a history of acute bronchiolitis.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":"22 1","pages":"83"},"PeriodicalIF":5.3000,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694905/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1186/s12940-023-01035-1","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis.
Methods: A nested case-control retrospective study was performed at the Kaohsiung Medical University Hospital systems between 2009 and 2019. The average concentration of PM10, PM2.5, SO2, NO, NO2, and NOX was collected for three, six, and twelve months after the first infected episode. Adjusted regression models were employed to evaluate the association between asthma and air pollution exposure after bronchiolitis.
Results: Two thousand six hundred thirty-seven children with acute bronchiolitis were included. Exposure to PM10, PM2.5, SO2, NO, NO2, and NOX in the three, six, and twelve months following an episode of bronchiolitis was found to significantly increase the risk of preschool asthma in infants with a history of bronchiolitis.(OR, 95%CI: PM10 = 1.517-1.559, 1.354-1.744; PM2.5 = 2.510-2.603, 2.148-3.061; SO2 = 1.970-2.040, 1.724-2.342; ; NO = 1.915-1.950, 1.647-2.272; NO2 = 1.915-1.950, 1.647-2.272; NOX = 1.752-1.970, 1.508-2.252) In a sensitive analysis of hospitalized infants, only PM10, PM2.5, SO2, and NO were found to have significant effects during all time periods. (OR, 95%CI: PM10 = 1.613-1.650, 1.240-2.140; PM2.5 = 2.208-2.286, 1.568-3.061; SO2 = 1.679-1.622, 1.197-2.292; NO = 1.525-1.557, 1.094-2.181) CONCLUSION: The presence of ambient PM10, PM2.5, SO2 and NO in the three, six, and twelve months following an episode of acute bronchiolitis has been linked to the development of preschool asthma in infants with a history of acute bronchiolitis.
期刊介绍:
Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology.
Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.