Relationship between chemical industrial environment and allergic skin diseases.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Acta biochimica Polonica Pub Date : 2023-12-03 DOI:10.18388/abp.2020_6797

Shaohua Fu, Minli Gong, Guisheng Xing

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引用次数: 0

Abstract

Objective: This study is an exploration of the relationship between chemical industrial environment and allergic skin diseases.

Methods: In this retrospective analysis, 200 patients with allergic skin diseases who worked or lived in a chemical industrial zone and were admitted in our hospital between January 2018 and January 2020 were enrolled as Group A. Besides, 500 patients with allergic skin disease who lived in Zhenhai New District, five kilometers away from the chemical radiation zone, were selected as Group B. The specific immunoglobulin E (IgE) levels were determined by Western blotting. The allergen positivity, as well as allergen positivity between different age, sex and body mass index (BMI) were compared between the two groups. The positive food-specific allergen IgE antibody (sIgE) and positive inhalational sIgE were compared between the two groups.

Results: The positive rate of total IgE and inhalational sIgE in Group A was higher than that in Group B (P<0.05), while there was no significant difference in positive rate in food sIgE between the two groups (P>0.05). In Group A, the differences in positive rates of total IgE, food-induced sIgE and inhalational sIgE were not significant between patients with different ages, sexes and BMI (P>0.05). There was no significant difference between the two groups in sIgE positive rates of wheat, mango, soybean/peanut/cashew nut combination, limb/beef combination, crab/shrimp/fish combination, milk and egg white (P>0.05). The positive rates of inhalational sIgE in tree combination and dust mites/household dust mites combination in Group A were higher than those in Group B (P<0.05), but had no significant difference between the two groups in the positive rates of inhalational sIgE in Humulus japonicus, mold combination 1, cockroach, cat/dog hair combination, and ragweed/artemisia combination (P>0.05).

Conclusion: Chemical industrial environment is closely associated with allergic dermatosis, and the positive rate of total IgE and inhalational sIgE increases significantly in patients living there.

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化学工业环境与过敏性皮肤病的关系

目的:探讨化学工业环境与过敏性皮肤病的关系。方法:回顾性分析2018年1月至2020年1月在我院住院的化学工业区工作或生活的过敏性皮肤病患者200例，作为a组。选择500例居住在距化学辐射区5公里的镇海新区的过敏性皮肤病患者作为b组。采用免疫blotting检测特异性免疫球蛋白E (IgE)水平。比较两组过敏原阳性率，以及不同年龄、性别、体质指数(BMI)之间的过敏原阳性率。比较两组食物特异性过敏原IgE抗体(sIgE)阳性和吸入性sIgE阳性。结果:A组总IgE、吸入sIgE阳性率明显高于B组(P0.05)。A组患者总IgE、食物性sIgE、吸入性sIgE阳性率在不同年龄、性别、BMI之间差异均无统计学意义(P>0.05)。小麦、芒果、大豆/花生/腰果组合、四肢/牛肉组合、蟹/虾/鱼组合、牛奶和蛋清的sIgE阳性率两组间差异不显著(P>0.05)。A组树木组合、尘螨/家尘螨组合吸入性sIgE阳性率高于B组(P0.05)。结论:化学工业环境与过敏性皮肤病密切相关，生活在化学工业环境中的患者总IgE和吸入性sIgE阳性率明显升高。

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来源期刊

Acta biochimica Polonica 生物-生化与分子生物学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Acta Biochimica Polonica is a journal covering enzymology and metabolism, membranes and bioenergetics, gene structure and expression, protein, nucleic acid and carbohydrate structure and metabolism.