Unsaturation of serine lipids modulating the interaction of a cytosporone with models of the external leaflet of tumorigenic cell membranes

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry and Physics of Lipids Pub Date : 2023-11-30 DOI:10.1016/j.chemphyslip.2023.105363

Guilherme Nuñez Jaroque, Augusto Leonardo dos Santos, Patrícia Sartorelli, Luciano Caseli

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Abstract

Cytosporone-B was isolated from fungi and incorporated in models of tumorigenic cell membranes using palmitoyloleoylglycerophosphoserine (POPS) and dipalmitoyl glycerophosphoserine (DPPS) lipids. While for DPPS, the compound condensed the monolayer and decreased the surface compressional modulus, it expanded and kept the compressional modulus for POPS. Hysteresis for compression-expansion cycles was more sensitive for POPS than for DPPS, while a high degree of destabilization was observed for POPS. As observed with infrared spectroscopy and Brewster angle microscopy, specific changes were selective regarding molecular organization and morphology. Atomic force microscopy for transferred monolayers as Langmuir-Blodgett films also confirmed such specificities. We believe these data can help understand the mechanism of action of bioactive drugs in lipid interfaces at the molecular level.

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丝氨酸脂的不饱和调节胞啡酮与致瘤细胞膜外小叶模型的相互作用。

从真菌中分离Cystoporone-B，并利用棕榈酰甘油磷酸丝氨酸(POPS)和双棕榈酰甘油磷酸丝氨酸(DPPS)脂质将其加入致瘤细胞膜模型。而对于DPPS，该化合物使单层压缩并降低了表面压缩模量，而对于POPS，该化合物使其膨胀并保持了表面压缩模量。压缩-膨胀循环的迟滞对持久性有机污染物比DPPS更敏感，而持久性有机污染物的不稳定程度较高。通过红外光谱和布鲁斯特角显微镜观察，分子的组织和形态发生了选择性的变化。原子力显微镜对转移单层如Langmuir-Blodgett膜也证实了这种特异性。我们相信这些数据有助于在分子水平上理解生物活性药物在脂质界面中的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry and Physics of Lipids 生物-生化与分子生物学

CiteScore

7.60

自引率

2.90%

发文量

审稿时长

40 days

期刊介绍： Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.