Evaluation of quality of life's prognostic factors in people with functional seizures

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2024-06-01 DOI:10.1016/j.neurol.2023.09.007

P. Capitaine , B. Thomas , A. Gradel , T. Ferté , O. Branchard , E. Frison , V. Renaudeau , J. Aupy

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引用次数: 0

Abstract

Aims

Functional non-epileptic seizures significantly impact the quality of life of patients. We aimed to identify prognostic factors associated with the quality of life in individuals with functional non-epileptic seizures.

Subjects and methods

Adult patients diagnosed with definite or documented functional seizures based on LaFrance's criteria (n = 72) were enrolled at the time of diagnosis. Quality of life was assessed using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) at diagnosis and at a six-month follow-up. Demographic and medical information was collected, and psychiatric comorbidities were evaluated using validated scales.

Results

Comparisons between diagnosis and follow-up did not reveal any factors associated with improvement in quality of life at six months after diagnosis. However, multivariable analysis, adjusted for age, sex, diagnosis delay, and frequency of functional seizures showed a significant cross-sectional relationship with a QOLIE-31 score decrease of 0.66 [95% CI −0.93;−0.39], −0.32 [−0.61; −0.03], and −0.22 [−0.42; −0.02] for an increase of 1 point of BDI-2 score, BAI score, and CTQ score respectively.

Conclusion

Psychiatric comorbidities, particularly depression and anxiety, are associated with worse quality of life in patients with functional seizures. This underscores the crucial importance of multidisciplinary care involving both neurological and psychiatric expertise when managing individuals with functional seizures.

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功能性癫痫发作患者生活质量预后因素的评价。

目的:功能性非癫痫性发作显著影响患者的生活质量。我们的目的是确定与功能性非癫痫性发作患者生活质量相关的预后因素。对象和方法:根据LaFrance标准诊断为明确或记录的功能性癫痫发作的成年患者(n=72)在诊断时入选。在诊断时和6个月随访时，使用癫痫生活质量量表-31 (QOLIE-31)评估患者的生活质量。收集人口统计和医学信息，并使用有效的量表评估精神疾病。结果:诊断和随访的比较没有发现任何与诊断后6个月生活质量改善相关的因素。然而，经年龄、性别、诊断延迟和功能性癫痫发作频率调整后的多变量分析显示，与QOLIE-31评分下降有显著的横断面关系:0.66 [95% CI -0.93;-0.39]， -0.32 [-0.61;-0.03]， -0.22 [-0.42;-0.02]， BDI-2评分、BAI评分、CTQ评分分别提高1分。结论:精神合并症，特别是抑郁和焦虑，与功能性癫痫发作患者的生活质量下降有关。这强调了在管理功能性癫痫患者时，涉及神经学和精神病学专业知识的多学科护理的至关重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.