Effects of glyphosate herbicide ingestion on kidney function in rats on a balanced diet.

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Bruno Reis Moreira Nacano, Marcia Bastos Convento, Andréia Silva de Oliveira, Rafaela Castino, Bianca Castino, Clara Versolato Razvickas, Eduardo Bondan, Fernanda Teixeira Borges
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Abstract

Introduction: Glyphosate is the most widely used herbicide worldwide and in Brazil. There is currently increasing concern about the effects of glyphosate on human health. The Brazilian Institute for Consumer Protection showed data on the presence of glyphosate in some of Brazil's most consumed ultra-processed products. Currently, regulations on the upper limit for these residues in ultra-processed foods have yet to be established by the National Health Surveillance, and ultra-processed food consumption is independently associated with an increased risk of incident chronic kidney disease.

Methods: Since an unbalanced diet can interfere with kidney function, this study aims to investigate the effect of daily intake of 5 mg/kg bw glyphosate in conjunction with a balanced diet and the possible impact on renal function in rats. Kidney function, kidney weight, markers of renal injury, and oxidative stress were evaluated.

Results: There was a decrease in kidney weight. The main histopathological alterations in renal tissues were vacuolation in the initial stage and upregulation of the kidney injury marker KIM-1. Renal injury is associated with increased production of reactive oxygen species in mitochondria.

Conclusion: This study showed changes in the kidney of rats exposed to a balanced diet with glyphosate, suggesting a potential risk to human kidney. Presumably, ultra-processed food that contain glyphosate can potentiate this risk. The relevance of these results lies in drawing attention to the need to regulate glyphosate concentration in ultra-processed foods in the future.

草甘膦除草剂摄入对均衡饮食大鼠肾功能的影响。
草甘膦是世界上使用最广泛的除草剂,在巴西也是如此。目前,人们越来越关注草甘膦对人类健康的影响。巴西消费者保护研究所(Brazilian Institute for Consumer Protection)公布了一些巴西消费最多的超加工产品中草甘膦含量的数据。目前,国家卫生监督机构尚未制定超加工食品中这些残留物的上限规定,而超加工食品的消费与慢性肾脏疾病发生风险的增加独立相关。方法:由于饮食不平衡会干扰肾脏功能,本研究旨在探讨每日摄入5 mg/kg bw草甘膦结合平衡饮食对大鼠肾脏功能的影响及其可能的影响。评估肾功能、肾脏重量、肾损伤标志物和氧化应激。结果:大鼠肾脏重量减轻。肾脏组织的主要病理改变是初始阶段的空泡化和肾损伤标志物KIM-1的上调。肾损伤与线粒体活性氧的产生增加有关。结论:本研究显示,草甘膦均衡饮食对大鼠肾脏的影响,提示草甘膦对人类肾脏有潜在风险。据推测,含有草甘膦的超加工食品可能会增加这种风险。这些结果的相关性在于引起人们对未来需要调节超加工食品中草甘膦浓度的关注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.20
自引率
16.70%
发文量
208
审稿时长
16 weeks
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