Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

IF 16 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
ACS Nano Pub Date : 2023-12-02 DOI:10.1021/acsnano.3c06019
Dengshuai Wei*, Yong Sun*, Hu Zhu* and Qinrui Fu*, 
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引用次数: 3

Abstract

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external stimuli, such as lasers and ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, etc., and thus have been widely used in biomedical applications. Due to the characteristics of the tumor microenvironment (TME), stimuli-responsive polymers that cater specifically to the TME have been extensively used to prepare smart nanovehicles for the targeted delivery of therapeutic and diagnostic agents to tumor tissues. Compared to conventional drug delivery nanosystems, TME-responsive nanosystems have many advantages, such as high sensitivity, broad applicability among different tumors, functional versatility, and improved biosafety. In recent years, a great deal of research has been devoted to engineering efficient stimuli-responsive polymeric nanosystems, and significant improvement has been made to both cancer diagnosis and therapy. In this review, we summarize some recent research advances involving the use of stimuli-responsive polymer nanocarriers in drug delivery, tumor imaging, therapy, and theranostics. Various chemical stimuli will be described in the context of stimuli-responsive nanosystems. Accordingly, the functional chemical groups responsible for the responsiveness and the strategies to incorporate these groups into the polymer will be discussed in detail. With the research on this topic expending at a fast pace, some innovative concepts, such as sequential and cascade drug release, NIR-II imaging, and multifunctional formulations, have emerged as popular strategies for enhanced performance, which will also be included here with up-to-date illustrations. We hope that this review will offer valuable insights for the selection and optimization of stimuli-responsive polymers to help accelerate their future applications in cancer diagnosis and treatment.

Abstract Image

Abstract Image

刺激反应聚合物纳米系统在癌症治疗中的应用。
刺激响应聚合物可以通过改变自身的疏/亲水性、可降解性、可电离性等特性,对活性氧(ROS)、谷胱甘肽(GSH)、pH等内部刺激、酶等生物刺激以及激光、超声等外部刺激做出反应,从而广泛应用于生物医学领域。由于肿瘤微环境(TME)的特点,专门针对TME的刺激反应聚合物已被广泛用于制备智能纳米载体,用于将治疗和诊断药物靶向递送到肿瘤组织。与传统的药物递送纳米系统相比,tme响应纳米系统具有灵敏度高、适用于不同肿瘤、功能通用性强、生物安全性高等优点。近年来,人们对高效的刺激反应聚合物纳米系统进行了大量的研究,并在癌症诊断和治疗方面取得了重大进展。在这篇综述中,我们总结了刺激反应性聚合物纳米载体在药物传递、肿瘤成像、治疗和治疗学方面的最新研究进展。各种化学刺激将在刺激反应纳米系统的背景下描述。因此,负责响应性的功能化学基团以及将这些基团纳入聚合物的策略将被详细讨论。随着对这一主题的研究的快速发展,一些创新的概念,如顺序和级联药物释放,NIR-II成像和多功能配方,已经成为提高性能的流行策略,这里也将包括最新的插图。我们希望这一综述能够为刺激反应聚合物的选择和优化提供有价值的见解,以帮助加速其在癌症诊断和治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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