Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs.

IF 3.7 1区医学 Q2 GERIATRICS & GERONTOLOGY

European Review of Aging and Physical Activity Pub Date : 2023-11-29 DOI:10.1186/s11556-023-00333-4

Yu Chang Chen, Wang-Chun Chen, Chia-Wei Liu, Wei-Yu Huang, ICheng Lu, Chi Wei Lin, Ru Yi Huang, Jung Sheng Chen, Chi Hsien Huang

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引用次数: 0

Abstract

Background: Resistance training (RT) and nutritional supplementation are recommended for the management of sarcopenia in older adults. However, optimal RT intensity for the treatment of sarcopenia has not been well investigated.

Methods: This network meta-analysis aims to determine the comparative effectiveness of interventions for sarcopenia, taking RT intensity into consideration. RT intensity was classified into light-to-moderate intensity RT(LMRT), moderate intensity RT(MRT), and moderate-to-vigorous intensity RT(MVRT) based on percentage of one repetition maximum (%1RM) and/or rating of perceived exertion.

Results: A total of 50 RCTs (N = 4,085) were included after screening 3,485 articles. The results confirmed that RT with or without nutrition was positively associated with improved measures of muscle strength and physical performance. Regarding RT intensity, LMRT only demonstrated positive effects on hand grip (aerobic training + LMRT + nutrition: mean difference [MD] = 2.88; 95% credential intervals [CrI] = 0.43,5.32). MRT provided benefits on improvement in the 30-s chair stand test (repetitions) (MRT: MD = 2.98, 95% CrI = 0.35,5.59), timed up and go test (MRT: MD = -1.74, 95% CrI: = -3.34,-0.56), hand grip (MRT: MD = 2.44; 95% CrI = 0.03,5.70), and leg press (MRT: MD = 8.36; 95% CrI = 1.87,13.4). MVRT also improved chair stand test repetitions (MVRT: MD = 5.64, 95% CrI = 0.14,11.4), gait speed (MVRT + nutrition: MD = 0.21, 95% CrI = 0.003,0.48), appendicular skeletal muscle index (MVRT + nutrition: MD = 0.25, 95% CrI = 0.01,0.5), and leg press (MVRT: MD = 14.7, 95% CrI: 5.96,22.4; MVRT + nutrition: MD = 17.8, 95% CrI: 7.55,28.6).

Conclusion: MVRT had greater benefits on muscle mass, lower extremity strength, and physical performance compared to MRT. Increasing RT intensity may be recommended for sarcopenic older adults.

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中度阻力训练对老年肌肉减少症患者足够吗?随机对照试验的系统回顾和网络荟萃分析。

背景:阻力训练(RT)和营养补充被推荐用于老年人肌肉减少症的治疗。然而，治疗肌肉减少症的最佳放疗强度尚未得到很好的研究。方法:本网络荟萃分析的目的是在考虑放疗强度的情况下，确定肌肉减少症干预措施的相对有效性。根据单次最大重复次数的百分比(%1RM)和/或感知运动的等级，将放射治疗强度分为轻至中等强度放射治疗(LMRT)、中等强度放射治疗(MRT)和中至剧烈放射治疗(MVRT)。结果:筛选3485篇文献后，共纳入50项rct (N = 4085)。结果证实，有或没有营养的RT与肌肉力量和身体表现的改善呈正相关。在训练强度方面，LMRT仅对握力有积极影响(有氧训练+ LMRT +营养:平均差值[MD] = 2.88;95%可信区间[CrI] = 0.43,5.32)。MRT在30秒椅立测试(重复)(MRT: MD = 2.98, 95% CrI = 0.35,5.59)、计时和行走测试(MRT: MD = -1.74, 95% CrI = -3.34，-0.56)、握把(MRT: MD = 2.44;95% CrI = 0.03, 5.70),腿压(捷运:MD = 8.36;95% CrI = 1.87,13.4)。MVRT还改善了椅立试验重复数(MVRT: MD = 5.64, 95% CrI = 0.14,11.4)、步速(MVRT +营养:MD = 0.21, 95% CrI = 0.003,0.48)、尾骨骼肌指数(MVRT +营养:MD = 0.25, 95% CrI = 0.01,0.5)和腿压(MVRT: MD = 14.7, 95% CrI: 5.96,22.4;MVRT +营养:MD = 17.8, 95% CrI: 7.55,28.6)。结论:与MRT相比，MVRT在肌肉质量、下肢力量和身体机能方面有更大的好处。对于肌肉减少的老年人，建议增加放疗强度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Review of Aging and Physical Activity 医学-老年医学

CiteScore

8.60

自引率

1.60%

发文量

审稿时长

>12 weeks

期刊介绍： European Review of Aging and Physical Activity (EURAPA) disseminates research on the biomedical and behavioural aspects of physical activity and aging. The main issues addressed by EURAPA are the impact of physical activity or exercise on cognitive, physical, and psycho-social functioning of older people, physical activity patterns in advanced age, and the relationship between physical activity and health.