An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Obesity & Metabolic Syndrome Pub Date : 2023-12-30 Epub Date: 2023-12-01 DOI:10.7570/jomes23042

Sandeep Karna, Ki-Woon Kang

引用次数: 0

Abstract

Heart failure (HF) is a clinical syndrome characterized by myocardial dysfunction leading to inefficient blood filling or ejection. Regardless of the etiology, various mechanisms, including adipokine hypersecretion, proinflammatory cytokines, stem cell proliferation, oxidative stress, hyperglycemic toxicity, and autonomic nervous system dysregulation in the pericardial fat (PCF), contribute to the development of HF. PCF has been directly associated with cardiovascular disease, and an increased PCF volume is associated with HF. The PCF acts as neuroendocrine tissue that is closely linked to myocardial function and acts as an energy reservoir. This review aims to summarize each mechanism associated with PCF in HF.

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心力衰竭患者心包脂肪过多的机制综述。

心衰(HF)是一种以心肌功能障碍导致血液充盈或射血效率低下为特征的临床综合征。无论病因如何，心包脂肪(PCF)的多种机制，包括脂肪因子高分泌、促炎细胞因子、干细胞增殖、氧化应激、高血糖毒性和自主神经系统失调，都有助于心包脂肪的发展。PCF与心血管疾病直接相关，PCF体积增加与HF相关。PCF作为神经内分泌组织，与心肌功能密切相关，并作为能量储存库。本文综述了HF中PCF的相关机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

8.30

自引率

9.60%

发文量

审稿时长

19 weeks

期刊介绍： The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).