Correlation between red blood cell distribution width/platelet count and prognosis of newly diagnosed diffuse large B-cell lymphoma.

IF 2.3 Q2 HEMATOLOGY

Blood Research Pub Date : 2023-12-31 Epub Date: 2023-11-30 DOI:10.5045/br.2023.2023156

Xiaobo Liu, Yanliang Bai, Ying Liu, Weiya Li, Yabin Cui, Jinhui Xu, Xingjun Xiao, Xiaona Niu, Kai Sun

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Abstract

Background: Red blood cell distribution width/platelet count ratio (RPR) is a reliable prognostic assessment indicator for numerous diseases. However, no studies to date have examined the relationship between RPR and the prognosis of diffuse large B-cell lymphoma (DLBCL). Therefore, this study aimed to investigate the correlation between RPR and the clinical characteristics and prognosis of patients with diffuse large B-cell lymphoma.

Methods: We retrospectively studied 143 patients with newly diagnosed DLBCL and used the median value as the RPR threshold. We also investigated the correlation of pretreatment RPR level with clinical characteristics and its impact on DLBCL prognosis.

Results: Using the median value as the cut-off, patients with DLBCL were divided into a low RPR group (＜0.0549) and a high RPR group (≥0.0549). Patients in the high RPR group were older, had a later Ann Arbor stage, were prone to bone marrow invasion, and had a higher National Comprehensive Cancer Network International Prognostic Index score (P＜0.05). A survival analysis showed that progression-free survival (PFS) (P=0.003) and overall survival (OS) (P＜0.0001) were significantly shorter in the high versus low RPR group. A multifactorial Cox analysis showed that bone marrow invasion and elevated lactate dehydrogenase (LDH) were separate risk factors for PFS (P＜0.05), while an RPR ≥0.0549 and elevated LDH were separate risk factors for OS (P＜0.05).

Conclusion: A high RPR (≥0.0549) in patients with newly diagnosed DLBCL is an independent risk factor for a poor prognosis.

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新诊断弥漫性大b细胞淋巴瘤红细胞分布宽度/血小板计数与预后的关系

背景:红细胞分布宽度/血小板计数比(RPR)是许多疾病可靠的预后评估指标。然而，目前还没有研究证实RPR与弥漫性大b细胞淋巴瘤(DLBCL)预后之间的关系。因此，本研究旨在探讨RPR与弥漫性大b细胞淋巴瘤患者临床特征及预后的相关性。方法:对143例新诊断的DLBCL患者进行回顾性研究，采用中位数作为RPR阈值。我们还研究了预处理RPR水平与临床特征的相关性及其对DLBCL预后的影响。结果:以中位数为临界值，将DLBCL患者分为低RPR组(PP=0.003)和总生存期(OS)组(ppp)。结论:新诊断DLBCL患者高RPR(≥0.0549)是预后不良的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Research HEMATOLOGY-

CiteScore

3.70

自引率

0.00%

发文量