Investigating the gut microbiota's influence on psoriasis and psoriatic arthritis risk: a Mendelian randomization analysis.

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Precision Clinical Medicine Pub Date : 2023-09-15 eCollection Date: 2023-09-01 DOI:10.1093/pcmedi/pbad023
Nianzhou Yu, Jiayi Wang, Yuancheng Liu, Yeye Guo
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引用次数: 1

Abstract

Background: Numerous investigations have revealed the interplay between gut microbiota (GM) and psoriasis (Ps) and psoriatic arthritis (PsA). However, the causal relationship between them remains unknown.

Methods: We curated a collection of genetic variants (P < 1 × 10-5) associated with GM (n = 18 340) derived from the MiBioGen study. To explore the intricate relationship between GM and Ps as well as PsA, we harnessed the comprehensive resources of the FinnGen database, encompassing a vast cohort of individuals, including 4510 Ps cases and 212 242 controls and 1637 PsA cases and 212 242 controls. Mendelian randomization (MR) was used, including an inverse variance weighting method, followed by a sensitivity analysis to verify the robustness of the results.

Results: For Ps, some bacterial taxa, including Lactococcus, Ruminiclostridium 5, and Eubacterium fissicatena, were identified as risk factors; but Odoribacter demonstrated a protective effect against Ps. In the case of PsA, Lactococcus, Verrucomicrobiales, Akkermansia, Coprococcus 1, and Verrucomicrobiaceae were identified as risk factors; Odoribacter and Rikenellaceae exhibited a protective effect against the development of PsA.

Conclusion: Our study establishes a causal link between the GM and Ps and PsA. These findings provide insights into the underlying mechanisms and suggest potential therapeutic targets.

研究肠道微生物群对银屑病和银屑病关节炎风险的影响:孟德尔随机分析。
背景:大量研究揭示了肠道微生物群(GM)与银屑病(Ps)和银屑病关节炎(PsA)之间的相互作用。然而,它们之间的因果关系尚不清楚。方法:我们收集了来自MiBioGen研究的与GM相关的遗传变异(P -5) (n = 18 340)。为了探索GM、Ps和PsA之间的复杂关系,我们利用了FinnGen数据库的综合资源,其中包括大量个体,包括4510例Ps病例和212 242例对照,以及1637例PsA病例和212 242例对照。采用孟德尔随机化(MR),包括方差逆加权法,然后进行敏感性分析以验证结果的稳健性。结果:乳球菌、5型反刍芽胞杆菌和裂裂真杆菌是Ps的危险因素;在PsA病例中,乳球菌(Lactococcus)、Verrucomicrobiales、Akkermansia、Coprococcus 1和Verrucomicrobiaceae被确定为危险因素;气味杆菌和里氏菌科对PsA的发生具有保护作用。结论:我们的研究建立了GM与Ps和PsA之间的因果关系。这些发现提供了对潜在机制的见解,并提出了潜在的治疗靶点。
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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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