Alzheimer's Disease and Cancer: Common Targets.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-01-01 DOI:10.2174/0113895575263108231031132404

Xueqing Yang, Jinlian Dai, Chenglong Wu, Zongliang Liu

引用次数: 0

Abstract

There is growing epidemiologic evidence of an inverse association between cancer and AD. In addition, both cell survival and death are regulated by the same signaling pathways, and their abnormal regulation may be implicated in the occurrence and development of cancer and AD. Research shows that there may be a common molecular mechanism between cancer and AD. This review will discuss the role of GSK3, DAPK1, PP2A, P53 and CB2R in the pathogenesis of cancer and AD and describe the current research status of drug development based on these targets.

查看原文本刊更多论文

阿尔茨海默病和癌症:共同目标。

越来越多的流行病学证据表明，癌症与AD呈负相关。此外，细胞的生存和死亡都受相同的信号通路调控，其异常调控可能与癌症和AD的发生发展有关。研究表明，在癌症和AD之间可能存在共同的分子机制。本文将讨论GSK3、DAPK1、PP2A、P53和CB2R在癌症和AD发病机制中的作用，并描述基于这些靶点的药物开发的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567