Association between co-infection with Chlamydia trachomatis or Mycoplasma genitalium and cervical lesions in HPV-positive population in Hunan, China: a cross-sectional study.

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2023-11-29 DOI:10.1186/s13027-023-00544-5

Mengjie Jiang, Hui Ding, Ling He, Danning Xu, Ping Jiang, Haoneng Tang, Qian Wang, Xuemei Wang, Lingli Tang

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引用次数: 0

Abstract

Objectives: The aim of this study was to determine the prevalence of Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) among HPV-positive women undergoing colposcopy at the Second Xiangya Hospital of Central South University, Hunan, China. Additionally, we aimed to assess the impact of C. trachomatis or M. genitalium co-infection with HPV on the severity of cervical lesions.

Methods: We collected HPV data, cervical cytology results, and demographic information from 439 women attending colposcopy. Cervical swabs were obtained for simultaneous amplification testing (SAT) of C. trachomatis and M. genitalium. Multivariate logistic regression analyses were performed to examine the association between sexually transmitted pathogens and cervical lesions.

Results: Among the participants, C. trachomatis was detected in 17 (3.87%) individuals, and M. genitalium in 16 (3.64%) individuals. There was no co-infection of C. trachomatis and M. genitalium. The highest prevalence of M. genitalium was observed in women aged 19-30 years (10.20%; 95% CI, 1.41-18.99%), with a subsequent decline in prevalence with increasing age (Ptrend = 0.014). The most common HPV subtype in our study was HPV52 (30.79%), followed by HPV16 (18.62%), HPV58 (16.95%), and HPV53 (10.02%). Infection with HPV16 (OR = 3.43, 95% CI, 2.13-5.53), HPV31 (OR = 3.70, 95% CI, 1.44-9.50), and HPV33 (OR = 3.71, 95% CI, 1.43-9.67) was associated with an increased severity of cervical lesions, while HPV53 infection was not likely to lead to advanced cervical lesions (OR = 0.45, 95% CI, 0.23-0.89). The leukocyte level in vaginal secretions (P = 0.042) and cervical cytology results (P < 0.001) showed associations with the degree of cervical lesions. However, there was no significant association between C. trachomatis or M. genitalium infection and the severity of cervical lesions, nor with their co-infection with HPV16.

Conclusions: There was no correlation between co-infection of Chlamydia trachomatis or Mycoplasma genitalium and the degree of cervical lesions in HPV-positive population in Hunan, China. Our findings emphasized the need to pay more attention to M. genitalium infection among young women. Increased levels of leukocytes in vaginal secretions may be linked to cervical lesions. HPV16, HPV31, and HPV33 in Hunan province, China, may exhibit higher cervical pathogenicity.

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中国湖南hpv阳性人群中沙眼衣原体或生殖道支原体合并感染与宫颈病变的相关性:一项横断面研究

目的:研究在湖南省中南大学湘雅第二医院接受阴道镜检查的hpv阳性妇女中沙眼衣原体(CT)和生殖支原体(MG)的流行情况。此外，我们的目的是评估沙眼原体或生殖道支原体合并HPV感染对宫颈病变严重程度的影响。方法:我们收集了439名参加阴道镜检查的女性的HPV数据、宫颈细胞学结果和人口统计学信息。取宫颈拭子进行沙眼原体和生殖支原体同时扩增检测(SAT)。采用多变量logistic回归分析来检验性传播病原体与宫颈病变之间的关系。结果:沙眼原体检出17例(3.87%)，生殖道支原体检出16例(3.64%)。沙眼衣原体与生殖支原体未合并感染。生殖支原体感染率最高的是19-30岁的女性(10.20%;95% CI, 1.41-18.99%)，随着年龄的增长，患病率随之下降(p趋势= 0.014)。我们研究中最常见的HPV亚型是HPV52(30.79%)，其次是HPV16(18.62%)、HPV58(16.95%)和HPV53(10.02%)。感染HPV16 (OR = 3.43, 95% CI, 2.13-5.53)、HPV31 (OR = 3.70, 95% CI, 1.44-9.50)和HPV33 (OR = 3.71, 95% CI, 1.43-9.67)与宫颈病变严重程度增加相关，而HPV53感染不太可能导致宫颈病变进展(OR = 0.45, 95% CI, 0.23-0.89)。阴道分泌物白细胞水平(P = 0.042)和宫颈细胞学检查结果(P)结论:湖南省hpv阳性人群沙眼衣原体和生殖道支原体合并感染与宫颈病变程度无相关性。我们的研究结果强调需要更多地关注年轻女性的生殖器支原体感染。阴道分泌物中白细胞水平升高可能与宫颈病变有关。HPV16、HPV31和HPV33在中国湖南省可能表现出较高的宫颈致病性。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.