Micro-nanoemulsion and nanoparticle-assisted drug delivery against drug-resistant tuberculosis: recent developments.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-30 DOI:10.1128/cmr.00088-23
Simpal Kumar Suman, Natarajan Chandrasekaran, C George Priya Doss
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引用次数: 0

Abstract

Tuberculosis (TB) is a major global health problem and the second most prevalent infectious killer after COVID-19. It is caused by Mycobacterium tuberculosis (Mtb) and has become increasingly challenging to treat due to drug resistance. The World Health Organization declared TB a global health emergency in 1993. Drug resistance in TB is driven by mutations in the bacterial genome that can be influenced by prolonged drug exposure and poor patient adherence. The development of drug-resistant forms of TB, such as multidrug resistant, extensively drug resistant, and totally drug resistant, poses significant therapeutic challenges. Researchers are exploring new drugs and novel drug delivery systems, such as nanotechnology-based therapies, to combat drug resistance. Nanodrug delivery offers targeted and precise drug delivery, improves treatment efficacy, and reduces adverse effects. Along with nanoscale drug delivery, a new generation of antibiotics with potent therapeutic efficacy, drug repurposing, and new treatment regimens (combinations) that can tackle the problem of drug resistance in a shorter duration could be promising therapies in clinical settings. However, the clinical translation of nanomedicines faces challenges such as safety, large-scale production, regulatory frameworks, and intellectual property issues. In this review, we present the current status, most recent findings, challenges, and limiting barriers to the use of emulsions and nanoparticles against drug-resistant TB.

微纳米乳剂和纳米颗粒辅助给药治疗耐药结核病:最新进展。
结核病(TB)是一个主要的全球卫生问题,也是仅次于COVID-19的第二大流行传染病杀手。它是由结核分枝杆菌(Mtb)引起的,由于耐药,治疗变得越来越具有挑战性。1993年,世界卫生组织宣布结核病为全球卫生紧急事件。结核病的耐药性是由细菌基因组的突变驱动的,而这种突变可能受到长期药物暴露和患者依从性差的影响。耐药结核病的发展,如多重耐药、广泛耐药和完全耐药,构成了重大的治疗挑战。科学家们正在探索新的药物和新的药物输送系统,例如基于纳米技术的疗法,以对抗耐药性。纳米给药提供了靶向和精确的给药,提高了治疗效果,减少了不良反应。随着纳米级药物输送,具有有效治疗效果的新一代抗生素、药物再利用以及能够在较短时间内解决耐药性问题的新治疗方案(组合)可能是临床环境中有希望的治疗方法。然而,纳米药物的临床转化面临着诸如安全性、大规模生产、监管框架和知识产权问题等挑战。在这篇综述中,我们介绍了使用乳剂和纳米颗粒治疗耐药结核病的现状、最新发现、挑战和限制障碍。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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