Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226.

IF 3.4 3区生物学 Q1 Agricultural and Biological Sciences

Botanical Studies Pub Date : 2023-11-30 DOI:10.1186/s40529-023-00406-8

Chia-Hao Chang, George Hsiao, Shih-Wei Wang, Juei-Yu Yen, Shu-Jung Huang, Wei-Chiung Chi, Tzong-Huei Lee

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引用次数: 0

Abstract

Background: Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity.

Results: Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1-14. Their structures were determined by spectroscopic analysis as three previously undescribed C₁₃-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4-14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC₅₀ value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC₅₀ value of 0.8 ± 0.3 µM.

Conclusions: Three previously unreported compounds 1-3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively.

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药用真菌毛毛菌Km1226的化学成分。

背景:内生真菌已被证明是新颖天然产物的丰富来源，具有广泛的生物活性和更高水平的结构多样性。结果:对从海滨药材大黄竹中分离得到的globosum毛毛菌Km1226的液态和固态发酵产物进行化学分析，分离到化合物1 ~ 14。它们的结构通过光谱分析确定为三种先前描述的c13聚酮，即aureonitol C (1)， mollipilins G(2)和H(3)，以及11种已知化合物4-14。其中，mollipilin A(5)在lps诱导的BV-2小胶质细胞中表现出明显的一氧化氮生成抑制活性，IC50值为0.7±0.1µM; chaetoglobosin D(10)在人内皮祖细胞(EPCs)中表现出有效的抗血管生成特性，IC50值为0.8±0.3µM。结论:分离鉴定了3个以前未报道的化合物1-3。Mollipilin A(5)和chaetoglobosin D(10)可能分别被开发为抗炎和抗血管生成的先导药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Botanical Studies 生物-植物科学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

2.4 months

期刊介绍： Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.