Efficacy and Safety of Radiotherapy Combined with Pyrotinib in the Treatment of HER2-Positive Breast Cancer with Brain Metastases.

IF 3.3 4区 医学 Q2 ONCOLOGY
Breast Cancer : Targets and Therapy Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI:10.2147/BCTT.S440427
Jie Huang, Wenqiang Zhu, Qiangzhi Duan, Chaomang Zhu, Xueling Shi, Hongyu Zhao, Peng Cai, Duojie Li
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Abstract

Purpose: To explore the efficacy and safety of pyrotinib combined with different radiotherapy modes in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) patients with brain metastasis (BM).

Patients and methods: This study is a retrospective analysis of patients diagnosed with BM who underwent treatment with pyrotinib between November 2018 and April 2023. A total of 66 patients were administered radiotherapy in conjunction with pyrotinib (Group A), while 26 patients received pyrotinib as a standalone treatment (Group B). Within Group A, 18 patients underwent conventional fractionated radiotherapy (2Gy/F), while 48 patients received hyperfractionated radiotherapy (HFRT) (≥3Gy/F). The primary endpoints were intracranial progression-free survival (IC-PFS) and overall survival (OS). The secondary endpoints were objective response rate (ORR) and clinical benefit rate (CBR).

Results: The ORR of Group A was 54.5% (36/66), while the ORR of Group B was 34.6% (9/26) (P= 0.047). The CBR of Group A was 89.4% (59/66) and that of Group B was 69.2% (18/26) (P= 0.041). The IC-PFS between Group A and Group B were 12 months and 8 months, respectively (P< 0.001), and the OS were 20 months and 16 months, respectively (P= 0.065). In Group A, the IC-PFS and OS between the conventional fractionation radiotherapy group and the HFRT group were 10 months and 12 months, respectively (P= 0.001) and 16 months and 24 months, respectively (P< 0.001). No serious adverse reactions were observed in Group A and Group B.

Conclusion: For HER2-positive BC patients with BM, it is recommended to adopt the treatment mode of HFRT combined with pyrotinib, which can improve the local control and survival of patients.

放疗联合罗替尼治疗her2阳性乳腺癌脑转移的疗效和安全性。
目的:探讨吡罗替尼联合不同放疗方式治疗人表皮生长因子受体2 (HER2)阳性乳腺癌(BC)合并脑转移(BM)患者的疗效和安全性。患者和方法:本研究是对2018年11月至2023年4月期间接受罗替尼治疗的BM患者的回顾性分析。66例患者联合吡罗替尼进行放疗(A组),26例患者单独接受吡罗替尼治疗(B组)。A组中,18例患者接受常规分割放疗(2Gy/F), 48例患者接受超分割放疗(HFRT)(≥3Gy/F)。主要终点是颅内无进展生存期(IC-PFS)和总生存期(OS)。次要终点为客观缓解率(ORR)和临床获益率(CBR)。结果:A组的ORR为54.5% (36/66),B组的ORR为34.6% (9/26)(P= 0.047)。A组CBR为89.4% (59/66),B组为69.2% (18/26)(P= 0.041)。A组和B组的IC-PFS分别为12个月和8个月(P< 0.001), OS分别为20个月和16个月(P= 0.065)。A组常规分割放疗组与HFRT组的IC-PFS和OS分别为10个月和12个月(P= 0.001), 16个月和24个月(P< 0.001)。结论:对于her2阳性BC合并BM患者,推荐采用HFRT联合吡罗替尼的治疗模式,可提高患者的局部控制和生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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