Anti-cardiolipin and anti-beta 2 glycoprotein I antibodies in patients with type 1 diabetes.

Chaima Mrizak, Amani Mankai, Mariam Ghozzi, Sarra Melayah, Ibtissem Ghedira
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Abstract

To determine the frequency of anti-phospholipid antibodies (aPL) in particular anti-cardiolipin antibodies (aCL) and anti-beta 2 glycoprotein I antibodies (aβ2GPI) in Tunisian patients with type 1 diabetes. One hundred and two patients with type 1 diabetes (34 children, 68 adults) were studied. As control groups, we used sera of 156 adults and 65 children without type 1 diabetes. aCL and aβ2GPI were detected by ELISA. The frequency of aPL was significantly higher in type 1 diabetes patients than in control group (18.6% vs. 5.9%, p < 0.001). In patients, aPL were significantly more frequent in adults than in children (25% vs. 5.9%, p = 0.04). In the whole group of type 1 diabetes, aCL were significantly more frequent in long-term type 1 diabetes than in inaugural type 1 diabetes (21.2% vs. 7.2%, p = 0.04). In adults, aβ2GPI were significantly more frequent in inaugural type 1 diabetes than in controls (20% vs. 1.9%, p < 0.001), and the frequency of aCL was significantly higher in long-term type 1 diabetes than in controls (21.9% vs. 1.9%, p < 0.001). Female adults with type 1 diabetes had high frequency of aCL and aβ2GPI.

1型糖尿病患者的抗心磷脂和抗β 2糖蛋白I抗体
测定突尼斯1型糖尿病患者中抗磷脂抗体(aPL),特别是抗心磷脂抗体(aCL)和抗β2糖蛋白I抗体(a - β 2gpi)的频率。研究了102例1型糖尿病患者(34例儿童,68例成人)。作为对照组,我们使用了156名成人和65名无1型糖尿病的儿童的血清。ELISA法检测aCL和a - β 2gpi。1型糖尿病患者aPL发生率明显高于对照组(18.6% vs. 5.9%, p
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