Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY
Psychiatry and Clinical Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-01-03 DOI:10.1111/pcn.13626
Klaas Bahnsen, Marie-Louis Wronski, Johanna Louise Keeler, Joseph A King, Quirina Preusker, Theresa Kolb, Kerstin Weidner, Veit Roessner, Fabio Bernardoni, Stefan Ehrlich
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引用次数: 0

Abstract

Background: Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield-specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels.

Methods: T1-weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross-sectionally and longitudinally in females with acute AN (n = 165 at baseline, n = 110 after partial weight restoration), healthy female controls (HCs; n = 271), and females after long-term recovery from AN (n = 79) using linear models.

Results: We found that most hippocampal subfield volumes were significantly reduced in patients with AN compared with HCs (~-3.9%). Certain areas such as the subiculum exhibited no significant reduction in the acute state of AN, while other areas, such as the hippocampal tail, showed strong decreases (~-9%). Following short-term weight recovery, most subfields increased in volume. Comparisons between participants after long-term weight-recovery and HC yielded no differences. The hippocampal tail volume was positively associated with leptin levels in AN independent of body mass index.

Conclusions: Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared with other major mental disorders (e.g. major depressive disorder and schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery.

神经性厌食症患者海马亚区的差异纵向变化。
背景:神经性厌食症(Anorexia neurosa, AN)是一种以饮食限制、害怕体重增加和身体形象扭曲为特征的精神障碍。最近的研究表明,对学习和记忆至关重要的海马体可能在AN中受到影响,但子场特异性影响尚不清楚。在这里,我们研究了急性AN的海马亚区改变,体重恢复后的变化及其与瘦素水平的关系。方法:采用FreeSurfer进行t1加权磁共振成像扫描。我们使用线性模型对急性AN女性(基线时n = 165,部分体重恢复后n = 110)、健康女性(HC时n = 271)和AN长期恢复后女性(n = 79)的22个左右半球海马亚区进行横断面和纵向比较。结果:我们发现,与HC相比,AN组大部分海马亚区体积显著减少(~ - 3.9%)。在急性AN状态下,某些区域(如耻骨下)没有明显的减少,而其他区域(如海马尾)则表现出强烈的减少(~ - 9%)。在短期重量恢复后,大多数子油田的体积都增加了。长期体重恢复和HC后的参与者之间的比较没有差异。海马尾体积与a的瘦素水平呈正相关,独立于BMI。结论:我们的研究提供了AN和HC患者海马亚区体积差异的证据,并且在体重康复后几乎完全恢复正常。这些改变在空间上是不均匀的,与其他主要精神障碍(如重度抑郁症、精神分裂症)相比更为明显。我们提供了新的见解,将低瘦素血症与海马亚区改变联系起来,提示瘦素正常化在AN恢复中的临床相关性。这篇文章受版权保护。版权所有。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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