Association of oral lichen planus and psoriasis: a case-control study.

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Quintessence international Pub Date : 2024-01-23 DOI:10.3290/j.qi.b4706089

Lucia Rodríguez-Fonseca, Claudia Llorente-Alvarez, Santiago Llorente-Pendás, María García-Pola

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引用次数: 0

Abstract

Objective: The aim of the present study was to investigate whether psoriasis disease constitutes a risk factor for OLP, by assessing the prevalance of psoriasis in a test group with OLP and the control group without.

Method and materials: A cohort of consecutive patients diagnosed clinically and histologically with OLP between 2014 and 2022 was analyzed. The results were contrasted with those obtained in control series matched for age and sex. The correlations between OLP and sex, age, tobacco, alcohol consumption, and psoriasis were assessed using Pearson chi-square test. Multivariate regression analysis was performed to evaluate the association between psoriasis and OLP. For the assessment of the quality of the statistical models, the Akaike information criterion was used.

Results: The study involved 1,016 patients; 738 women (72.6%) and 278 men (27.4%). The average age was 59.38 ± 12.55 years. Of 508 patients with OLP, 16 (3.15%) had comorbid psoriasis, and this was 5 (0.98%) in the control group. Age, sex, smoking, and alcohol habits were not predictive variables in the relationship between psoriasis and OLP in these patients. There were statistically significant differences in relation to the number of locations, with greater extension in patients with OLP and psoriasis (P = .002). According to the multivariate analysis, the odds ratio of OLP for psoriasis was 3.13 (95% CI 1.20-9.68).

Conclusions: This is the first study showing the potential association between psoriasis and OLP, and the results should be considered to improve knowledge of comorbidity of OLP. Based on the results, it is recommended that clinicians collect data regarding history of psoriasis in patients with OLP, and consider possible multiple intraoral locations.

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口腔扁平苔藓与牛皮癣的关系:一项病例对照研究。

目的:本研究的目的是探讨银屑病是否构成OLP的合并症，并阐明抑郁和焦虑治疗的效果。方法和材料:我们分析了2014-2022年临床和组织学诊断为OLP的连续患者队列。结果与年龄和性别相匹配的对照系列的结果进行了对比。使用Pearson卡方检验评估OLP与性别、年龄、吸烟、饮酒、牛皮癣、抑郁和焦虑治疗的相关性。采用多元回归分析评价银屑病与OLP之间的关系。采用赤池信息准则(Akaike Information Criterion, AIC)评价统计模型的质量。结果:共纳入1016例患者，其中女性738例(72.6%)，男性278例(27.4%)。平均年龄59.38(±12.55)岁。508例OLP患者中16例(3.15%)合并银屑病，对照组5例(0.98%)合并银屑病。年龄、性别、吸烟和饮酒习惯不是银屑病与OLP患者相关性的预测变量。多因素分析显示，银屑病的OLP奇比(OR)为3.13,1.20-9.68，与单因素分析相比，抑郁药物的OLP奇比(OR)更高(OR 1.88, 1.13-3.19)，焦虑药物的OLP奇比(OR 2.06, 1.18-2.70)。结论:据我们所知，这是第一个显示OLP患者牛皮癣潜在风险的研究，我们的结果应该被考虑在内，以提高对OLP合并症的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quintessence international 医学-牙科与口腔外科

CiteScore

3.30

自引率

5.30%

发文量

审稿时长

1 months

期刊介绍： QI has a new contemporary design but continues its time-honored tradition of serving the needs of the general practitioner with clinically relevant articles that are scientifically based. Dr Eli Eliav and his editorial board are dedicated to practitioners worldwide through the presentation of high-level research, useful clinical procedures, and educational short case reports and clinical notes. Rigorous but timely manuscript review is the first order of business in their quest to publish a high-quality selection of articles in the multiple specialties and disciplines that encompass dentistry.