Endothelial Biomarkers in Critically Ill COVID-19 Patients: Potential Predictors of the Need for Dialysis.

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2024-01-01 Epub Date: 2023-11-28 DOI:10.1159/000535035

Marza de Sousa Zaranza, Gdayllon Cavalcante Meneses, Reinaldo Barreto Oriá, Alice Maria Costa Martins, Natalia Linhares Ponte Aragão, Nilcyeli Linhares Aragão, Saskya Roberta Rodrigues de Andrade, Nicole Coelho Lopes, Letícia Machado de Araújo, Ranieri Sales de Souza Santos, Álvaro Rolim Guimarães, Ana Paula Pires Lázaro, Andrea Mazza Beliero, Márcia Maria Pinheiro Dantas, Sandra Mara Brasileiro Mota, Geraldo Bezerra da Silva Júnior, Polianna Lemos Moura Moreira Albuquerque, Elizabeth De Francesco Daher

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引用次数: 0

Abstract

Introduction: The aim of this was to evaluate the function of vascular biomarkers to predict the need for hemodialysis in critically ill patients with COVID-19.

Methods: This is a prospective study with 58 critically ill patients due to COVID-19 infection. Laboratory tests in general and vascular biomarkers, such as VCAM-1, syndecan-1, angiopoietin-1, and angiopoietin-2, were quantified on intensive care unit (ICU) admission.

Results: There was a 40% death rate. VCAM and Ang-2/Ang-1 ratio on ICU admission were associated with the need for hemodialysis. Vascular biomarkers (VCAM-1, syndecan-1, angiopoietin-2/angiopoietin-1 ratio) were predictors of death and their cutoff values were useful to stratify patients with a worse prognosis. In the multivariate cox regression analysis with adjusted models, VCAM-1 (OR 1.13 [CI 95%: 1.01-1.27]; p = 0.034) and Ang-2/Ang-1 ratio (OR 4.87 [CI 95%: 1.732-13.719]; p = 0.003) were associated with the need for dialysis.

Conclusion: Vascular biomarkers, mostly VCAM-1 and Ang-2/Ang-1 ratio, showed better efficiency to predict the need for hemodialysis in critically ill COVID-19 patients.

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COVID-19危重患者的内皮生物标志物:透析需求的潜在预测因素

目的:评价血管生物标志物在预测COVID-19危重患者血液透析需求中的作用。方法:对58例新冠肺炎感染危重患者进行前瞻性研究。在重症监护病房(ICU)入院时，对一般和血管生物标志物(如VCAM-1、Syndecan-1、血管生成素-1和血管生成素-2)的实验室检测进行量化。结果:死亡率为40%。ICU入院时VCAM和Ang-2/Ang-1比值与血液透析需求相关。血管生物标志物(VCAM-1、Syndecan-1、angiopoetin-2/ anogiopoetin-1比值)是死亡预测因子，其临界值可用于对预后较差的患者进行分层。在调整模型的多变量cox回归分析中，VCAM-1 [O.R.1.13 (c.i. 95%: 1.01 - 1.27);p= 0.034]和Ang-2/Ang-1比值[p= 0.034]4.87 (ci .95%: 1.732 - 13.719);P = 0.003]与透析需求相关。结论:血管生物标志物以VCAM-1和Ang-2/Ang-1比值预测COVID-19危重症患者血液透析需求效果较好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.