Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma.

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2023-11-28 DOI:10.1186/s13027-023-00557-0

Hans Prakash Sathasivam, Sangeetha Passu Davan, Szu May Chua, Rahmuna Fazlina Rohaizat, Rohaizam Japar, Zahirrudin Zakaria, Abd Razak Ahmad, Hasmah Hashim, Shashi Gopalan Marimuthu, Yew Toong Liew, Doh Jeing Yong, Pappathy Vairavan, Avatar Singh Mohan Singh, Benjamin Hong Beng Goh, Zulkifli Yusof, Khairul Azlan Shahril Abu Dahari, Ali Haron, Masaany Mansor, Mohd Zambri Ibrahim, Shiraz Qamil Muhammad Abdul Kadar, Mohamad Hazri Hamal, Wan Emelda Wan Mohamad

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引用次数: 0

Abstract

Background: In addition to the conventional aetiologic agents of oropharyngeal squamous cell carcinoma (OPSCC) such as tobacco usage, alcohol consumption and betel quid usage, it has been established that a proportion of OPSCC are driven by persistent oncogenic human papillomavirus (HPV) infections. Currently, there is a lack of data on the burden of HPV- associated OPSCC in Asian countries including Malaysia.

Methods: A cross-sectional multicentre study with tissue analysis of Malaysian patients diagnosed with primary OPSCC within a five-year period, from 2015 to 2019 between 01/01/2015 to 31/12/2019 was undertaken. Determination of HPV status was carried out using p16INK4a immunohistochemistry on tissue microarrays constructed from archived formalin-fixed paraffin-embedded tissue.

Results: From the cases identified, 184 cases had sufficient tissue material for analysis. Overall, median age at diagnosis was 63.0 years (IQR = 15) and 76.1% of patients were males. In our cohort, 35.3% of patients were Indian, 34.2% were Chinese, 21.2% were Malay and 9.2% were from other ethnicities. The estimated prevalence of HPV-associated OPSCC in our cohort was 31.0% (CI 24.4-38.2%). The median age for the HPV-associated OPSCC sub-group of patients was not significantly lower than the median age of patients with HPV-independent OPSCC. More than half of HPV-associated OPSCC was seen in patients of Chinese ethnicity (54.4%). Patients with HPV-associated OPSCC had a much better overall survival than patients with HPV-independent OPSCC (Log rank test; p < 0.001). Patients with HPV-associated OPSCC with no habit-related risk factors such as smoking, were found to have much better overall survival when compared to all other sub-groups.

Conclusions: The findings from our study suggests that prevalence of HPV-associated OPSCC in Malaysia, though not as high as some developed countries, is however on an upward trend. HPV-associated OPSCC appears to be more frequently encountered in patients of Chinese ethnicity. Conventional risk-factors associated with OPSCC such as smoking, alcohol consumption and betel quid chewing should still be considered when estimating prognosis of patients with HPV-associated OPSCC.

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马来西亚一项口咽鳞状细胞癌的多中心研究结果。

背景:除了传统的口咽鳞状细胞癌(OPSCC)的病因学因素，如吸烟、饮酒和使用槟榔液，已经确定一部分的口咽鳞状细胞癌是由持续的致癌人类乳头瘤病毒(HPV)感染驱动的。目前，在包括马来西亚在内的亚洲国家，缺乏与HPV相关的OPSCC负担的数据。方法:对2015年至2019年(2015年1月1日至2019年12月31日)5年期间诊断为原发性OPSCC的马来西亚患者进行横断面多中心研究和组织分析。采用p16INK4a免疫组化技术对归档的福尔马林固定石蜡包埋组织构建的组织微阵列进行HPV状态检测。结果:184例有足够的组织材料供分析。总体而言，诊断时的中位年龄为63.0岁(IQR = 15)， 76.1%的患者为男性。在我们的队列中，35.3%的患者是印度人，34.2%是中国人，21.2%是马来人，9.2%是其他种族。在我们的队列中，hpv相关OPSCC的估计患病率为31.0% (CI 24.4-38.2%)。hpv相关的OPSCC亚组患者的中位年龄并不显著低于hpv无关的OPSCC患者的中位年龄。超过一半的hpv相关OPSCC见于华人(54.4%)。hpv相关的OPSCC患者的总生存期比hpv无关的OPSCC患者好得多(Log rank检验;结论:我们的研究结果表明，马来西亚hpv相关的OPSCC患病率虽然不像一些发达国家那么高，但却呈上升趋势。hpv相关的OPSCC似乎更常见于华裔患者。在评估hpv相关OPSCC患者的预后时，仍应考虑与OPSCC相关的传统危险因素，如吸烟、饮酒和咀嚼槟榔液。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.