Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI:10.1080/10641955.2023.2285757

Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu

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引用次数: 0

Abstract

Objective: The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.

Methods: We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.

Results: We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01-1.51), p = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02-1.30), p = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01-1.30), p = 0.040]. The results were robust under all sensitivity analyses.

Conclusion: These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text].

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COVID-19与子痫前期/子痫之间的遗传倾向性:一项孟德尔随机研究

目的:本研究采用孟德尔随机(MR)设计，探讨COVID-19与子痫前期/子痫风险之间可能的因果关系。方法:我们估计了它们的遗传相关性，然后使用来自COVID-19易感性/住院全基因组关联研究和子痫前期/子痫数据集的汇总统计数据进行两样本孟德尔随机化分析。主要采用方差反加权法进行分析，并辅以加权中位数法和MR-Egger法。结果:我们发现COVID-19易感性与子痫前期/子痫之间存在显著的正遗传相关[OR = 1.23 (1.01-1.51)， p = 0.043]。同时，COVID-19住院治疗与子痫前期/子痫的高风险显著相关[OR = 1.15 (1.02-1.30)， p = 0.024]。与此一致的是，COVID-19住院与子痫前期风险升高相关[OR = 1.14， (1.01-1.30)， p = 0.040]。在所有敏感性分析下，结果都是稳健的。结论:这些结果提示COVID-19可能增加子痫前期/子痫的风险。预防或治疗干预措施的未来发展应强调这一点，以减轻COVID-19的并发症。[图:见正文]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.