Frailty is related to serum inflammageing markers: results from the VITAL study.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Yannick van Sleen, Sudarshan A Shetty, Marieke van der Heiden, Milou C A Venema, Nicolas Gutiérrez-Melo, Erik J M Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle, Delphine Sauce
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Abstract

Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of the SF-36. Serum/plasma levels of inflammageing markers and CMV/EBV seropositivity were measured using different techniques: Quanterix, Luminex or ELISA.All four measures of frailty strongly correlated with age and BMI. Nineteen biomarkers correlated with age, some in a linear fashion (IL-6, YKL-40), some only in the oldest age brackets (CRP), and some increased at younger ages and then plateaued (CCL2, sIL-6R). After correcting for age, biomarkers, such as IL-6, CRP, IL-1RA, YKL-40 and elastase, were associated with frailty. When corrected for BMI, the number of associations reduced further.In conclusion, inflammageing markers, particularly markers reflecting innate immune activation, are related to frailty. These findings indicate that health decline and the accumulation of deficits with age is accompanied with a low-grade inflammation which can be detected by specific inflammatory markers.

虚弱与血清炎症标志物有关:VITAL研究的结果。
虚弱描述了一种与年龄相关的状态,个体的脆弱性增加,对不良后果的适应能力下降。为了对虚弱进行评分,研究采用了问卷调查,如SF-36和EQ-5D-3L,或虚弱指数,这是一种基于缺陷积累的综合评分。此外,免疫系统的衰老通常伴随着低度炎症(炎症)状态。在这项前瞻性队列研究中,我们旨在将29种炎症循环标志物与虚弱指标联系起来,以了解衰老的机制。对317名年龄在25-90岁之间的参与者进行了虚弱指标和炎症标志物的评估。我们确定了四种不同的虚弱指标:基于31个缺陷的虚弱指数,EQ-5D-3L和SF-36的两个物理域。使用不同的技术(Quanterix, Luminex或ELISA)测量血清/血浆炎症标志物水平和CMV/EBV血清阳性。所有四项虚弱指标都与年龄和体重指数密切相关。19种生物标志物与年龄相关,有些呈线性(IL-6, YKL-40),有些仅在最年长的年龄组(CRP),有些在年轻时增加,然后趋于平稳(CCL2, sIL-6R)。在校正年龄后,生物标志物,如IL-6、CRP、IL-1RA、YKL-40和弹性蛋白酶与虚弱相关。当对BMI进行校正后,相关的数量进一步减少。总之,炎症标志物,特别是反映先天免疫激活的标志物,与脆弱有关。这些发现表明,随着年龄的增长,健康下降和缺陷的积累伴随着可以通过特定炎症标志物检测到的低度炎症。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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