Effectiveness of fibrin sealants in head and neck surgery: a systematic review protocol.

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES
Marie Nguyen, Andrew Foreman, Craig Lockwood
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引用次数: 0

Abstract

Objective: This review will investigate the effectiveness of fibrin sealants in adult patients who underwent head and neck surgery.

Introduction: Controlling bleeding is important in head and neck surgery. Complications involving nearby vital structures increase the risk of morbidity and mortality. Surgical tissue adhesives are used in addition to other traditional hemostatic methods to reduce surgical site bleeding. Fibrin sealants have shown some success compared with other tissue adhesives, but individual studies have been inconclusive.

Inclusion criteria: We will include studies comparing fibrin sealants with placebo or usual care in patients 18 years or older who have undergone soft tissue surgery of the head and neck with drain placement. Primary outcomes include wound complications and time to surgical drain removal. Secondary outcomes include length of hospital stay, drain volume output, surgical management of postoperative hematoma, rate of blood transfusions, and adverse reactions.

Methods: We will search electronic databases (PubMed, Embase, Cochrane Central Register of Controlled Trials CINAHL, Scopus, Web of Science) for studies published from 1975 onwards. Sources to be search for unpublished literature will include ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, MedNar, and ProQuest Dissertations and Theses. Titles, abstracts, and full-text papers will be assessed against the inclusion criteria by 2 independent reviewers. Study screening and selection will be performed, and critical appraisal conducted using the standardized JBI appraisal tools. Data will be extracted by 2 independent reviewers. Meta-analysis will be conducted for all outcomes where appropriate, with weighted mean differences for continuous data. Risk ratios will be used for dichotomous data. Certainty will be reported using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Review registration: PROSPERO CRD42023412820.

纤维蛋白密封剂在头颈部手术中的有效性:一项系统评价方案。
目的:本综述将探讨纤维蛋白密封剂在接受头颈部手术的成人患者中的有效性。在头颈部手术中,控制出血是很重要的。涉及附近重要结构的并发症增加了发病和死亡的风险。除其他传统止血方法外,还使用外科组织粘接剂来减少手术部位出血。与其他组织粘接剂相比,纤维蛋白密封剂已显示出一些成功,但个别研究尚无定论。纳入标准:我们将纳入在18岁或以上接受头颈部软组织手术并放置引流管的患者中比较纤维蛋白密封剂与安慰剂或常规护理的研究。主要结局包括伤口并发症和手术引流时间。次要结局包括住院时间、排液量、术后血肿的手术处理、输血率和不良反应。方法:我们将检索电子数据库(PubMed, Embase, Cochrane对照试验数据库)中1975年以后发表的研究。题目、摘要和全文论文将由2名独立审稿人根据纳入标准进行评估。将进行研究筛选和选择,并使用标准化的JBI评估工具进行关键评估。数据将由2名独立审稿人提取。在适当的情况下,将对所有结果进行meta分析,对连续数据进行加权平均差异分析。风险比将用于二分类数据。将使用建议、评估、发展和评估分级(GRADE)方法报告确定性。审核注册:PROSPERO CRD42023412820。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JBI evidence synthesis
JBI evidence synthesis Nursing-Nursing (all)
CiteScore
4.50
自引率
3.70%
发文量
218
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