Clinical evaluation of liposome-based gel formulation containing glycolic acid for the treatment of photodamaged skin.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2024-12-01 Epub Date: 2024-01-12 DOI:10.1080/1061186X.2023.2288998

Eskandar Moghimipour, Ali Gorji, Reza Yaghoobi, Anayatollah Salimi, Mahmoud Latifi, Maryam Aghakouchakzadeh, Somayeh Handali

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引用次数: 0

Abstract

Background: Long contact of UV causes skin damage. Glycolic acid (GA) as an alpha hydroxy acid is used to treat photodamaged skin. However, GA leads to side effects including; burning, erythema and peeling.Purpose: The aim of this study was to develop a controlled delivery systems loading GA in order to increasing its efficacy and lowering its side effects.Methods: Liposomes were evaluated for encapsulation efficiency, size and morphology. Optimized formulation was dispersed in HPMC gel bases and drug release kinetics were also studied. Clinical efficacy and safety of GA-loaded liposomal gel and GA gel formulation were evaluated in patients with photodamaged skin.Results: The EE% and average particle size of liposomes were 64 ±2.1 % and 317±3.6 nm, respectively. SEM image showed that liposomes were spherical in shape. In vitro release kinetics of GA from both formulations followed Weibull model. Clinical evaluation revealed that GA-loaded liposomal gel was more effective than GA gel formulation. Treatment with GA-loaded liposomal gel resulted in a statistically significant reduction in the scores of hyperpigmentation, fine wrinkling and lentigines. Moreover, liposomal gel formulation was able to minimize side effects of GA.Conclusion: According to the obtained results, the liposome-based gel formulation can be used as potential drug delivery system to enhance permeation of GA through skin layers and also reduce its side effects.

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含乙醇酸脂质体凝胶制剂治疗光损伤皮肤的临床评价。

长时间接触紫外线会造成皮肤损伤。乙醇酸(GA)是一种α羟基酸，用于治疗光损伤皮肤。然而，GA会导致副作用，包括;灼烧、红斑、脱皮。本研究的目的是开发一种装载GA的可控给药系统，以提高其疗效和降低其副作用。评价脂质体的包封效率、大小和形态。优化后的制剂在HPMC凝胶中分散，并对其释放动力学进行了研究。评价GA脂质体凝胶和GA凝胶制剂在光损伤皮肤患者中的临床疗效和安全性。脂质体的EE%为64±2.1%，平均粒径为317±3.6 nm。扫描电镜显示脂质体呈球形。两种制剂的GA体外释放动力学均符合Weibull模型。临床评价表明，负载GA脂质体凝胶比GA凝胶制剂更有效。用含ga的脂质体凝胶治疗可显著降低色素沉着、细皱纹和小痣的评分。此外，脂质体凝胶制剂能够减少GA的副作用。根据所得结果，脂质体凝胶制剂可以作为潜在的给药系统，增强GA通过皮肤层的渗透，并减少其副作用。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.