A Short Appraisal of Biomimetic Hydrogels to Improve Penetration of Poorly Permeable Drugs.

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Assay and drug development technologies Pub Date : 2023-11-01 Epub Date: 2023-11-21 DOI:10.1089/adt.2023.077
Dilpreet Singh, Sahil Arora, Vimal Arora
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引用次数: 0

Abstract

Effective drug delivery to target sites is critical for achieving desired therapeutic outcomes. However, the poor permeability of certain drugs poses significant challenges in achieving adequate drug concentrations at the desired locations. Biomimetic hydrogels have emerged as a promising approach to enhance the penetration of poorly permeable drugs. These hydrogels, designed to mimic natural biological systems, offer unique properties and functionalities that enable improved drug permeation. In this review, we provide a comprehensive appraisal of the role of biomimetic hydrogels in enhancing drug penetration. We discuss the design principles, properties, and mechanisms by which these hydrogels facilitate drug permeation. Specifically, we explore the applications and benefits of biomimetic hydrogels in controlled drug release, mimicking extracellular matrix microenvironments, promoting cell-mimetic interactions, and enabling targeted drug delivery. Through an examination of key studies and advancements, we highlight the potential of biomimetic hydrogels in enhancing drug penetration and their implications for therapeutic interventions. This review contributes to a deeper understanding of biomimetic hydrogels as a promising strategy for overcoming drug penetration challenges and advancing drug delivery systems, ultimately leading to improved therapeutic efficacy.

提高低渗透性药物渗透的仿生水凝胶的初步评价。
有效的药物递送到靶点是实现预期治疗结果的关键。然而,某些药物的渗透性差对在所需位置达到足够的药物浓度提出了重大挑战。仿生水凝胶已成为一种有前途的方法,以提高渗透性差的药物的渗透。这些水凝胶,旨在模仿自然生物系统,提供独特的性质和功能,使改善药物渗透。在这篇综述中,我们提供了一个全面的评价仿生水凝胶在提高药物渗透的作用。我们讨论了这些水凝胶促进药物渗透的设计原理、性质和机制。具体来说,我们探讨了仿生水凝胶在药物控制释放、模拟细胞外基质微环境、促进细胞模拟相互作用和靶向药物递送方面的应用和益处。通过对关键研究和进展的审查,我们强调了仿生水凝胶在增强药物渗透方面的潜力及其对治疗干预的影响。这篇综述有助于更深入地了解仿生水凝胶作为克服药物渗透挑战和推进药物传递系统的有前途的策略,最终导致提高治疗效果。
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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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