Effect of Modification Strategies on the Biological Activity of Peptides/Proteins

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2023-11-27 DOI:10.1002/cbic.202300481

Jian Ma, Dr. Liang Yan, Prof. Dr. Jingkui Yang, Prof. Dr. Yujian He, Dr. Li Wu

引用次数: 0

Abstract

Covalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.

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修饰策略对多肽/蛋白质生物活性的影响

生物活性肽/蛋白与功能片段的共价连锁是修饰和控制其生物分布、药代动力学、酶消化和毒性的有效策略。本文综述了不同修饰策略的特点及其对多肽/蛋白生物活性的影响，并阐述了它们的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).