Synergistic effect of Moringa oleifera and Allium sativum on BMI and lipid profile: A randomized controlled trial.

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Amna Sarfraz, Muhammad Imran Hussain, Ramisha Ibtisam, Annum Maha, Saher Asghar, Khizra Zubair, Khurram Sarfraz
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Abstract

We investigate the synergistic effect of Moringa oleifera and Allium sativum on hyperlipidemic patients. It was a randomized controlled trial. The sample size of this study was 60 patients who were divided into four equal groups (n=15) through a random sampling technique. Pre assessment of all participants was conducted at the start of the research. The control group (group A) received atorvastatin 10mg QD as well as placebo capsules. The treatment group 1 (group B) received atorvastatin 10mg QD as well as Moringa oleifera 2g (capsule 1g BID). Treatment group 2 (group C) received atorvastatin 10mg QD as well as Allium sativum 2g (capsule 1g BID). Lastly, treatment group 3 (Group D) received atorvastatin 10mg QD as well as combined Moringa oleifera 2g (capsule 1g BID) and Allium sativum 2g (capsule 1g BID). After an intervention of 45 days, post assessment was conducted. The results showed total cholesterol and triglycerides and low-density lipoprotein of participants of treatment group 3 who received both MO and AS were statistically significant (p<0.05). The group that was on Moringa oleifera supplements alone was found to be statistically significant (p<0.05). This study concluded that Moringa oleifera and Allium sativum considerably improved the BMI and lipid profile of participants.

辣木和葱对BMI和血脂的增效作用:一项随机对照试验。
探讨辣木和葱对高脂血症患者的增效作用。这是一项随机对照试验。本研究的样本量为60例患者,采用随机抽样方法分为4组(n=15)。在研究开始时对所有参与者进行了预评估。对照组(A组)给予阿托伐他汀10mg QD,同时给予安慰剂胶囊。治疗组1 (B组)给予阿托伐他汀10mg QD,辣木2g(胶囊1g BID)。治疗2组(C组)给予阿托伐他汀10mg QD,大蒜2g(胶囊1g BID)。最后,治疗3组(D组)给予阿托伐他汀10mg QD,联合辣木2g(胶囊1g BID)、葱2g(胶囊1g BID)。干预45 d后进行后评价。结果显示,治疗3组同时接受MO和AS治疗的参与者的总胆固醇、甘油三酯和低密度脂蛋白均有统计学意义(p
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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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