Impact of cytogenetic abnormalities in symptomatic multiple myeloma; a Japanese real-world analysis from Kansai Myeloma Forum

IF 0.7 Q4 HEMATOLOGY

Leukemia Research Reports Pub Date : 2023-01-01 DOI:10.1016/j.lrr.2023.100395

Aya Nakaya , Hirohiko Shibayama , Nobuhiko Uoshima , Ryosuke Yamamura , Satoshi Yoshioka , Kazunori Imada , Yuji Shimura , Masaaki Hotta , Toshimitsu Matsui , Satoru Kosugi , Hitoshi Hanamoto , Hitoji Uchiyama , Satoshi Yoshihara , Shin-ichi Fuchida , Yoshiyuki Onda , Yasuhiro Tanaka , Kensuke Ohta , Mitsuhiro Matsuda , Junya Kanda , Adachi Yoko , Masayuki Hino

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Abstract

To evaluate the specific prognostic value of CAs, we conducted an analysis of 923 symptomatic multiple myeloma patients. Among this cohort, 480 patients had complete data set of high-risk CAs by interphase fluorescent in situ hybridization at diagnosis. In the high-risk group analysis, the median OS of patients without CAs (n = 338, 72 %) was 6.5 years, patients with del(17p) (n = 42, 9 %) was 4.4 years, patients with t(4;14) or t(14;16) (n = 72, 15 %) was 4.4 years, and patients with double-positive CAs(del(17p) and t(4;14) or t(14;16)) (n = 18, 4 %) was 2.1 years (p = 0.032). Patients with double-positive CAs had a significantly worse prognosis.

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细胞遗传学异常对症状性多发性骨髓瘤的影响关西骨髓瘤论坛对日本现实世界的分析

为了评估ca的具体预后价值，我们对923例有症状的多发性骨髓瘤患者进行了分析。在该队列中，480例患者在诊断时通过间期荧光原位杂交具有完整的高危CAs数据集。在高危组分析中，无ca患者(n = 338, 72%)的中位OS为6.5年，del(17p)患者(n = 42,9 %)为4.4年，t(4;14)或t(14;16)患者(n = 72,15 %)为4.4年，双阳性ca (del(17p)和t(4;14)或t(14;16)患者(n = 18,4 %)为2.1年(p = 0.032)。双阳性ca患者预后明显较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Leukemia Research Reports Medicine-Oncology

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

23 weeks