Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting.

IF 5.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-11-25 DOI:10.1007/s11914-023-00839-x

Kulwinder Kaur, Ruby Sannoufi, Joseph S Butler, Ciara M Murphy

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Abstract

Purpose of review: This review aims to explore the potential of biomimetic hydrogels as an alternative to bone cement in vertebral body stenting (VBS), a minimally invasive treatment for vertebral compression fractures.

Recent findings: The use of bone cement in VBS procedures can lead to complications such as incomplete fracture reduction and cement leakage. Biomimetic hydrogels have gained significant attention as potential biomaterial alternatives for VBS due to their unique properties, including tuneable therapeutic and mechanical properties. Over the past decade, there has been significant advancements in the development of biomimetic hydrogels for bone regeneration, employing a wide range of approaches to enhance the structural and functional properties of hydrogels. Biomimetic hydrogels hold significant promise as safer and reparative alternatives to bone cement for VBS procedures. However, further research and development in this field are necessary to explore the full potential of hydrogel-based systems for vertebral bone repair.

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仿生水凝胶用于再生椎体支架植入。

综述目的:本综述旨在探讨仿生水凝胶作为椎体支架置入(VBS)中骨水泥替代品的潜力，这是一种微创治疗椎体压缩性骨折的方法。最近的研究发现:在VBS手术中使用骨水泥可导致并发症，如骨折复位不完全和水泥渗漏。仿生水凝胶由于其独特的性能，包括可调节的治疗和机械性能，作为潜在的VBS生物材料替代品而受到了极大的关注。在过去的十年中，用于骨再生的仿生水凝胶的发展取得了重大进展，采用了广泛的方法来增强水凝胶的结构和功能特性。仿生水凝胶作为一种更安全的修复性替代骨水泥用于VBS手术。然而，在这一领域的进一步研究和发展是必要的，以探索水凝胶为基础的系统在椎体骨修复中的全部潜力。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.