Indirect cardiac output assessment in a swine pediatric acute respiratory distress syndrome model

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-23 DOI:10.1016/j.resp.2023.104199

Lorenzo A. Miller , Rudolf K. Braun , Regina J. Golding , Michael Lasarev , Allison C. Rodgers , Sarah El-Meanawy , Timothy A. Hacker , Marlowe W. Eldridge , Awni M. Al-Subu

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引用次数: 0

Abstract

Purpose

To investigate the correlation between volume of carbon dioxide elimination (V̇CO₂) and end-tidal carbon dioxide (PETCO₂) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.

Methods

Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.

Results

Prior to ARDS induction, mean (SD) CO, V̇CO₂, PETCO₂, and dead space to tidal volume ratio (V_d/V_t) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO₂, and PETCO₂ were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO₂, PETCO₂, and V_d/V_t were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO₂ was 0.01 (−0.31 to 0.37) and between CO and PETCO₂ was 0.35 (−0.002 to 0.65).

Conclusion

ARDS may limit the utility of volumetric capnography to monitor CO.

查看原文本刊更多论文

猪小儿急性呼吸窘迫综合征模型的间接心输出量评估。

目的:探讨猪小儿急性呼吸窘迫综合征(ARDS)模型的二氧化碳消除量(V / CO2)和潮末二氧化碳(PETCO2)与心输出量(CO)的相关性。方法:采用油酸输注方法，对26头全麻机械通气仔猪在诱导ARDS前后的呼吸和血流动力学指标进行测定。结果:ARDS诱导前，平均(SD) CO、V (CO2)、PETCO2和死空潮容比(Vd/Vt)分别为4.16 (1.10)L/min、103.69 (18.06)ml/min、40.72 (3.88)mmHg和0.25(0.09)。平均CO、V³CO2和PETCO2的偏相关系数分别为0.44(95%可信区间0.18 ~ 0.69)和0.50(95%可信区间0.18 ~ 0.74)。ARDS诱导后，平均CO、V / CO2、PETCO2、Vd/Vt分别为3.33 (0.97)L/min、113.71 (22.97)ml/min、50.17 (9.73)mmHg、0.40(0.08)。CO与V ~ CO2的偏相关为0.01 (-0.31 ~ 0.37)，CO与PETCO2的偏相关为0.35(-0.002 ~ 0.65)。结论:ARDS可能限制容积容积造影监测CO的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.