Association between gut microbiota and its functional metabolites with prenatal depression in women

IF 4.3 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress Pub Date : 2023-11-17 DOI:10.1016/j.ynstr.2023.100592

Tianqu Xie , Xiaoxiao Fan , Hanghang Pang , Tianzi Zang , Ni Wu , Juan Liu , Ziying Li , Sha Li , Quanfei Zhu , Julia Elise Slack , Jinbing Bai , Yu Xu , Yanqun Liu

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引用次数: 0

Abstract

Background

The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs).

Methods

Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis.

Results

After controlling relevant covariates, our results found the higher the abundance of Candidatus_Soleaferrea, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to unclassified_c_Clostridia and NK4A214_group. However, results of this study did not support the moderating effect of plasma 5-HT on the association of Candidatus_Soleaferrea or propionic acid with prenatal depression.

Conclusions

Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy.

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肠道菌群及其功能代谢物与妇女产前抑郁症的关系

肠道菌群可能通过菌群-肠-脑轴影响情绪。本研究的目的是研究肠道微生物群及其代谢物，如短链脂肪酸(SCFAs)对产前抑郁症的影响，并确定5-羟色胺(5-HT)在与肠道微生物群及其代谢物(即SCFAs)相关的产前抑郁症中的作用。方法选取孕晚期孕妇86例。产前抑郁是通过爱丁堡产后抑郁量表以10分来确定的。收集了人口统计资料、粪便和血液样本。采用16S rRNA基因测序和液相色谱-质谱分析方法测定肠道菌群及其代谢产物SCFAs。采用气相色谱-质谱法测定血浆5-羟色胺含量。结果在控制相关变量后发现，Candidatus_Soleaferrea丰度越高，产前抑郁风险越低;丙酸浓度越高，产前抑郁的风险越高。我们的研究结果还发现，血浆5-HT越低，产前抑郁的风险越高，5-HT与unclassified_c_Clostridia和NK4A214_group有关。然而，本研究结果不支持血浆5-羟色胺在Candidatus_Soleaferrea或丙酸与产前抑郁的关联中的调节作用。结论妊娠期某些肠道菌群、scfa和血浆5-羟色胺的变化与产前抑郁有关。这一发现为基于饮食或益生菌的干预来调节怀孕期间的情绪提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

9.40

自引率

4.00%

发文量

审稿时长

48 days

期刊介绍： Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.