Bianca-Maria Tuchiu , Raluca-Ioana Stefan-van Staden , Jacobus (Koos) Frederick van Staden
{"title":"Fast on-site simultaneous electroanalysis of fusidic acid and betamethasone in pharmaceuticals and water samples using novel stochastic platform","authors":"Bianca-Maria Tuchiu , Raluca-Ioana Stefan-van Staden , Jacobus (Koos) Frederick van Staden","doi":"10.1016/j.elecom.2023.107625","DOIUrl":null,"url":null,"abstract":"<div><p>Fusidic acid and betamethasone are two pharmaceutically active compounds found in topical dosage forms. Sometimes, they can unintentionally wind up in surface water via skin washing. Therefore, a stochastic platform based on a type of calix[4]arene and polyaniline modified screen-printed electrode was developed for their on-site analysis. For both analytes, remarkably wide dynamic ranges (1.0 × 10<sup>−17</sup>–1.0 × 10<sup>−4</sup> for fusidic acid, and 1.0 × 10<sup>−18</sup>–1.0 × 10<sup>−3</sup> for betamethasone) and considerably low limits of quantitation (1.0 × 10<sup>−17</sup> for fusidic acid, and 1.0 × 10<sup>−18</sup> for betamethasone) were attained. Moreover, the proposed platform was successfully applied to real samples such as topical dosage form and surface water, obtaining recovery values higher than 90.0 % with relative standard deviation values below 0.1 %.</p></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S138824812300200X/pdfft?md5=b65e72697f1efa7d8fda6717c32cea95&pid=1-s2.0-S138824812300200X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electrochemistry Communications","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138824812300200X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}
引用次数: 0
Abstract
Fusidic acid and betamethasone are two pharmaceutically active compounds found in topical dosage forms. Sometimes, they can unintentionally wind up in surface water via skin washing. Therefore, a stochastic platform based on a type of calix[4]arene and polyaniline modified screen-printed electrode was developed for their on-site analysis. For both analytes, remarkably wide dynamic ranges (1.0 × 10−17–1.0 × 10−4 for fusidic acid, and 1.0 × 10−18–1.0 × 10−3 for betamethasone) and considerably low limits of quantitation (1.0 × 10−17 for fusidic acid, and 1.0 × 10−18 for betamethasone) were attained. Moreover, the proposed platform was successfully applied to real samples such as topical dosage form and surface water, obtaining recovery values higher than 90.0 % with relative standard deviation values below 0.1 %.
期刊介绍:
Electrochemistry Communications is an open access journal providing fast dissemination of short communications, full communications and mini reviews covering the whole field of electrochemistry which merit urgent publication. Short communications are limited to a maximum of 20,000 characters (including spaces) while full communications and mini reviews are limited to 25,000 characters (including spaces). Supplementary information is permitted for full communications and mini reviews but not for short communications. We aim to be the fastest journal in electrochemistry for these types of papers.