Gender differences in brain region activation during verbal fluency task as detected by fNIRS in patients with depression.

IF 3 4区医学 Q2 PSYCHIATRY

World Journal of Biological Psychiatry Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI:10.1080/15622975.2023.2287735

Hailong Lyu, Miaomiao Zhao, Pengfeng Xu, Ying Li, Chaonan Jiang, Haoyang Zhao, Wenjing Shen, Xiaohan Hu, Kaiqi Wang, Yi Xu, Manli Huang

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引用次数: 0

Abstract

Background: Gender plays a role in the mechanisms of depression, but fewer studies have focused on gender differences in the abnormal activation of brain regions when patients perform specific cognitive tasks.

Methods: A total of 110 major depressive disorder (MDD) patients and 106 healthy controls were recruited. The relative change in oxygen-haemoglobin (oxy-Hb) concentration during the verbal fluency task were measured by a 52-channel near-infra-red spectroscopy (NIRS) system. Differences in brain region activation between patients and healthy controls and between genders of depression patients were compared.

Results: MDD patients demonstrated significantly decreased [oxy-Hb] changes in the right inferior frontal gyrus (p = 0.043) compared to healthy controls. A marked increase in leftward functional language lateralisation in the inferior frontal gyrus was observed in the MDD group in contrast to the HC group (p = 0.039). Furthermore, female patients in the MDD group exhibited significant reductions in [oxy-Hb] changes in the right frontal region (specifically, the superior and middle frontal gyrus; p = 0.037) compared with male patients.

Conclusions: Gender impacts depression-related brain activation during cognitive tasks, potentially influencing depression's pathogenesis.

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fNIRS检测抑郁症患者言语流畅性任务时脑区激活的性别差异。

背景:性别在抑郁症的机制中起作用，但很少有研究关注患者在执行特定认知任务时大脑区域异常激活的性别差异。方法:共招募110例重度抑郁障碍(MDD)患者和106例健康对照。用52通道近红外光谱(NIRS)系统测量语言流畅性任务期间氧血红蛋白(oxy-Hb)浓度的相对变化。比较抑郁症患者与健康对照组及性别间脑区激活的差异。结果:与健康对照组相比，重度抑郁症患者右侧额下回的[oxy-Hb]变化显著降低(p = 0.043)。与HC组相比，MDD组额下回左侧功能性语言偏侧显著增加(p = 0.039)。此外，重度抑郁症组的女性患者右额叶区域(特别是额上回和中回)的[oxy-Hb]变化显著减少;P = 0.037)。结论:性别影响认知任务中抑郁相关的脑激活，可能影响抑郁的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Biological Psychiatry 医学-精神病学

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.