Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study.

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2024-01-01 Epub Date: 2023-11-22 DOI:10.1159/000535397
Sofía Morán-Ramos, Ruth Soriano-Cortés, Valeria Soto-Fuentes, Amyris Tenorio-Quiroz, Emmanuel Gervasio-Ortiz, Dulce Rico-Amador, Miguel Herrera, Mauricio Sierra-Salazar, Carlos A Aguilar-Salinas, Bárbara Antuna-Puente, Marcela Rodríguez-Flores
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引用次数: 0

Abstract

Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss.

Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing.

Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = -0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10-4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss.

Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.

术前肠道微生物多样性在Roux-en-Y胃旁路减肥反应中的作用:一项队列研究。
Roux-en-Y胃旁路术大大改变了肠道微生物组成,这可能与手术后代谢改善有关。在拉丁美洲人群中进行的研究很少,例如在成年人口中肥胖患病率超过30%的墨西哥。因此,本研究的目的是表征墨西哥队列Roux-en-Y胃旁路手术前后肠道微生物群结构的变化,并探讨手术相关的微生物群落变化是否与体重减轻有关。方法:对行Roux-en-Y胃分流术患者术前和术后12个月的生物标本进行检测。通过16S rRNA测序进行粪便微生物群鉴定。结果:20例接受Roux-en-Y胃分流术的患者术后12个月平均体重减轻66.8%。手术增加了α多样性估计(Chao, Shannon指数和观察到的操作分类单位(OTUs))。结论:术前微生物群可能倾向于某些与不太成功的结果相关的细菌变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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