Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes.

IF 2.6 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Korean Journal of Orthodontics Pub Date : 2023-11-25 Epub Date: 2023-09-05 DOI:10.4041/kjod23.091

Hannah Jeong, Jwa-Young Kim, Xiangguo Che, Je-Yong Choi, Insan Jang, Seong-Gon Kim

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引用次数: 0

Abstract

Objective: : To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models.

Methods: : Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group). The remaining 20 healthy rats were divided into control and 4HR groups. We administered 4HR subcutaneously at a weekly dose of 10 mg/kg until the rats were euthanized. At 16 weeks of age, whole blood was collected, and micro-computed tomography of the skull and femur was performed.

Results: : All craniofacial linear measurements were smaller in the STZ group than in the control group. The mandibular molar width was significantly smaller in the 4HR group than in the control group (P = 0.031) but larger in the STZ/4HR group than in the STZ group (P = 0.011). Among the diabetic animals, the STZ/4HR group exhibited significantly greater cortical bone thickness, bone mineral density, and bone volume than the STZ group. Serum testosterone levels were also significantly higher in the STZ/4HR group than in the STZ group.

Conclusions: : 4HR administration may have divergent effects on mandibular growth and bone mass in healthy and diabetic rats. In the context of diabetes, 4HR appears to have beneficial effects, potentially through the modulation of mitochondrial respiration.

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4-己基间苯二酚对生长大鼠面部骨骼发育的影响:对糖尿病的考虑。

目的:探讨4-己基间苯二酚(4HR)对成年雄性大鼠面部骨骼生长的长期影响，并以糖尿病动物模型为研究对象。方法:选用雄性大鼠40只。其中20只动物注射40 mg/kg链脲佐菌素(STZ)诱导1型糖尿病，分为STZ组和4HR注射组(STZ/4HR组)。其余20只健康大鼠分为对照组和4HR组。我们以每周10mg /kg的剂量皮下注射4HR，直到大鼠安乐死。在16周龄时，采集全血，并对颅骨和股骨进行微型计算机断层扫描。结果:STZ组所有颅面线性测量值均小于对照组。4HR组的下颌磨牙宽度明显小于对照组(P = 0.031)，而STZ/4HR组的下颌磨牙宽度明显大于STZ组(P = 0.011)。在糖尿病动物中，STZ/4HR组的皮质骨厚度、骨矿物质密度和骨体积均显著高于STZ组。血清睾酮水平在STZ/4HR组也明显高于STZ组。结论:4HR给药对健康大鼠和糖尿病大鼠下颌骨生长和骨量的影响可能不同。在糖尿病的情况下，4HR似乎具有有益的作用，可能通过线粒体呼吸的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Orthodontics DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

10.50%

发文量

审稿时长

>12 weeks

期刊介绍： The Korean Journal of Orthodontics (KJO) is an international, open access, peer reviewed journal published in January, March, May, July, September, and November each year. It was first launched in 1970 and, as the official scientific publication of Korean Association of Orthodontists, KJO aims to publish high quality clinical and scientific original research papers in all areas related to orthodontics and dentofacial orthopedics. Specifically, its interest focuses on evidence-based investigations of contemporary diagnostic procedures and treatment techniques, expanding to significant clinical reports of diverse treatment approaches. The scope of KJO covers all areas of orthodontics and dentofacial orthopedics including successful diagnostic procedures and treatment planning, growth and development of the face and its clinical implications, appliance designs, biomechanics, TMJ disorders and adult treatment. Specifically, its latest interest focuses on skeletal anchorage devices, orthodontic appliance and biomaterials, 3 dimensional imaging techniques utilized for dentofacial diagnosis and treatment planning, and orthognathic surgery to correct skeletal disharmony in association of orthodontic treatment.