Serum Cys C predicts acute kidney injury in patients with acute pancreatitis: A retrospective study

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Ningzhi Wang , Fei Han , Jiajia Pan , Guanghuai Yao , Yao Wang , Songxin Xu , Weiming Xiao , Yanbing Ding , Chunfang Xu
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Abstract

Background and study aims

We investigated the value of the serum cystatin C level as a potential predictor of acute kidney injury (AKI) in patients with acute pancreatitis (AP).

Patients and Methods

We retrospectively examined patients diagnosed with AP between January 2013 and December 2018. Patients were categorized into two groups based on their serum cystatin C levels after admission: the normal (n-Cys C group) and high serum cystatin C levels groups (h-Cys C group). Patients in the h-Cys C group demonstrated serum cystatin C levels ≥1.05 mg/L. Demographic parameters, laboratory data, and AP severity were compared between the two groups. Receiver operating curve (ROC) analysis was used to evaluate the efficacy of serum cystatin C in predicting persistent AKI.

Results

A total of 379 patients with AP were enrolled: 319 in the n-Cys C group and 60 in the h-Cys C group. Serum cystatin C levels were significantly higher in patients with severe acute pancreatitis (SAP) compared to moderate acute pancreatitis (MAP) (P< 0.05). The h-Cys C group had a higher BISAP score (P < 0.001). Incidences of organ failure and SAP were significantly higher in the h-Cys C group (P < 0.05). ROC analysis indicated that a serum cystatin C cutoff point of 1.055 mg/L optimally predicted persistent AKI (AUC = 0.711). For internal validation, we selected 545 AP patients, treated at our center from 2019 to 2022, including 54 AKI patients. ROC analysis in this validation group yielded a sensitivity of 100% and specificity of 90.9% (AUC = 0.916, 95% CI: 0.894–0.937).

Conclusion

Elevated serum cystatin C levels are sensitive indicators of adverse AKI prognosis in AP patients. The cystatin C level at admission can reflect a patient’s initial renal function status.

血清Cys C预测急性胰腺炎患者急性肾损伤:一项回顾性研究
背景和研究目的:我们研究了血清胱抑素C水平作为急性胰腺炎(AP)患者急性肾损伤(AKI)的潜在预测因子的价值。患者和方法:我们回顾性调查了2013年1月至2018年12月诊断为AP的患者。根据患者入院后血清胱抑素C水平分为正常组(n-Cys C组)和高血清胱抑素C水平组(h-Cys C组)。h-Cys C组患者血清胱抑素C水平≥1.05 mg/L。比较两组患者的人口学参数、实验室数据和AP严重程度。采用受试者工作曲线(ROC)分析评价血清胱抑素C在预测持续性AKI中的作用。结果:共有379例AP患者入组:n-Cys C组319例,h-Cys C组60例。重度急性胰腺炎(SAP)患者血清胱抑素C水平明显高于中度急性胰腺炎(MAP)患者(p)。结论:血清胱抑素C水平升高是AP患者AKI不良预后的敏感指标。入院时胱抑素C水平可以反映患者最初的肾功能状况。
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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
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