Prevention of transgenerational transmission of disease susceptibility through perinatal intervention.

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-03-28 Epub Date: 2023-11-22 DOI:10.1507/endocrj.EJ23-0381
Takahiro Nemoto, Norimasa Sagawa
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引用次数: 0

Abstract

The observational findings of Barker's original epidemiological studies were generalized as the Barker hypothesis and extended as the Developmental Origins of Health and Disease (DOHaD) theory. Barker et al. proposed that low birthweight (LBW) was associated with the occurrence of various noncommunicable diseases (NCDs) later in life. In other words, LBW itself is associated with the development of NCDs. This led to the DOHaD theory which proposed that an organism may have a specific period of developmental plasticity that is highly sensitive to the factors in its environment, and that combinations of acquired constitution and environmental factors may adversely affect health and risk the formation of NCDs. Due to undernutrition during the fetal period, the fetus acquires an energy-saving constitution called a thrifty phenotype due to adaptations of the metabolic and endocrine systems. It has been suggested that stimuli experienced early in development can persist throughout life and induce permanent physiological changes that predispose to NCDs. It has since become clear that the adverse environmental effects during the prenatal period are also intergenerationally and transgenerationally inherited, affecting the next generation. It has been shown that nutritional interventions such as methyl-donner and epigenome editing can restore some of the impaired functions and reduce the risk of developing some diseases in the next generation. This review thus outlines the mechanisms underlying various disease risk formations and their genetic programs for the next generation, which are being elucidated through studies based on our fetal undernutrition rat models.

通过围产期干预预防疾病易感性的跨代传播。
巴克最初的流行病学研究的观察发现被概括为巴克假说,并扩展为健康和疾病的发育起源理论。Barker等人提出,低出生体重(LBW)与生命后期各种非传染性疾病(ncd)的发生有关。换句话说,LBW本身与非传染性疾病的发展有关。这导致了DOHaD理论,该理论提出,生物体可能有一个特定的发育可塑性时期,对其环境因素高度敏感,后天体质和环境因素的结合可能对健康产生不利影响,并有形成非传染性疾病的风险。由于胎儿期营养不良,由于代谢和内分泌系统的适应,胎儿获得了一种被称为节俭型的节能体质。有研究表明,在发育早期经历的刺激可以持续一生,并诱发易患非传染性疾病的永久性生理变化。现在已经很清楚,产前期间的不利环境影响也是代际和跨代遗传的,影响到下一代。研究表明,甲基donner和表观基因组编辑等营养干预措施可以恢复一些受损的功能,并降低下一代患某些疾病的风险。因此,本文概述了各种疾病风险形成的机制及其下一代的遗传程序,这些机制正在通过基于我们的胎儿营养不良大鼠模型的研究得到阐明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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