Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ayushi Vaidhya, Kanika Ghildiyal, Divya Rajawat, Sonali Sonejita Nayak, Subhashree Parida, Manjit Panigrahi
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Abstract

The recent advances in high-throughput next-generation sequencing technologies have heralded the arrival of the Big Data era. As a result, the use of pharmacogenetics in drug discovery and individualized drug therapy has transformed the field of precision medicine. This paradigm shift in drug development programs has effectively reshaped the old drug development practices, which were primarily concerned with the physiological status of patients for drug development. Pharmacogenomics bridges the gap between pharmacodynamics and pharmacokinetics, advancing current diagnostic and treatment strategies and enabling personalized and targeted drug therapy. The primary goals of pharmacogenetic studies are to improve drug efficacy and minimize toxicities, to identify novel drug targets, to estimate drug dosage for personalized medicine, and to incorporate it as a routine diagnostic for disease susceptibility. Although pharmacogenetics has numerous applications in individualized drug therapy and drug development, it is in its infancy in veterinary medicine. The objective of this review is to present an overview of historical landmarks, current developments in various animal species, challenges and future perspectives of genomics in drug development and dosage optimization for individualized medicine in veterinary subjects.

Abstract Image

药物遗传学和药物基因组学在兽医临床实践中的应用综述。
高通量新一代测序技术的最新进展预示着大数据时代的到来。因此,药物遗传学在药物发现和个体化药物治疗中的应用改变了精准医学领域。药物开发项目的这种范式转变有效地重塑了旧的药物开发实践,旧的药物开发实践主要关注患者的生理状态。药物基因组学弥补了药效学和药代动力学之间的差距,促进了当前的诊断和治疗策略,并使个性化和靶向药物治疗成为可能。药物遗传学研究的主要目标是提高药物疗效和减少毒性,确定新的药物靶点,估计个体化药物的药物剂量,并将其作为疾病易感性的常规诊断。虽然药物遗传学在个体化药物治疗和药物开发中有许多应用,但在兽医学中还处于起步阶段。本文综述了基因组学在兽医学药物开发和个体化用药剂量优化方面的历史里程碑、各种动物物种的当前发展、挑战和未来展望。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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