Metabolic fate of DHA from regio- and stereospecific positions of triacylglycerols in a long-term feeding trial in rats.

Food research international (Ottawa, Ont.) Pub Date : 2023-12-01 Epub Date: 2023-10-25 DOI:10.1016/j.foodres.2023.113626

Yuqing Zhang, Marika Kalpio, Lingwei Tao, Guðmundur G Haraldsson, Haraldur G Guðmundsson, Xiangrong Fang, Kaisa M Linderborg, Yumei Zhang, Baoru Yang

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Abstract

This study investigated the impact of regio- and stereospecific position of docosahexaenoic acid (DHA) in dietary triacylglycerols (TAGs) on the fatty acid composition of tissues and organs in rats. Four-week feeding with TAGs containing DHA in sn-1, 2, or 3 position and palmitic acid in the remaining positions at a daily dosage of 500 mg TAG/kg body weight significantly increased the DHA content in all organs and tissues in rats, except in the brain, where the change in DHA level was not statistically significant. The group fed sn-1 DHA showed a significantly higher content of DHA in the plasma TAG than the group fed sn-3 DHA. The sn-3 DHA group had higher levels of DHA in the visceral fat compared to the sn-1, sn-2, as well as all other groups. This is the first study showing that DHA from sn-1 and sn-3 positions of dietary TAGs have differential accumulation in tissues. The new findings improved the current knowledge on the significance of TAG isomeric structure for the bioavailability and metabolic fate of DHA.

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在大鼠长期喂养试验中，三酰甘油区域和立体特异性位置的DHA代谢命运。

本研究探讨了二十二碳六烯酸(DHA)在膳食三酰甘油(tag)中的区域特异性和立体特异性位置对大鼠组织器官脂肪酸组成的影响。在sn-1、2、3位添加DHA标签，其余位置添加棕榈酸标签，每日剂量为500 mg TAG/kg体重，饲喂四周后，除脑外，大鼠各器官和组织中DHA含量均显著增加，DHA水平变化无统计学意义。饲喂sn-1 DHA组血浆TAG中DHA含量显著高于饲喂sn-3 DHA组。与sn-1、sn-2以及所有其他组相比，sn-3 DHA组内脏脂肪中的DHA含量更高。这是首次有研究表明，来自膳食标签sn-1和sn-3位置的DHA在组织中有不同的积累。这些新发现提高了目前对TAG异构体结构对DHA生物利用度和代谢命运的重要性的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Food research international (Ottawa, Ont.)

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